Bearn P E, McCollum C N, Marston A
Bloomsbury Vascular Unit, Middlesex Hospital, London, UK.
J R Coll Surg Edinb. 1994 Feb;39(1):1-5.
A major constraint in vascular surgery is the failure of the currently available prosthetic grafts to match the patency of autogenous vein below the inguinal ligament. Endothelial seeding aims to produce an endothelial lining which is otherwise absent from prosthetics. This could improve patency by preventing thrombosis and the release of mitogens by activated platelets implicated in the development of neointimal hyperplasia. Experimental evidence supports the potential of the technique but clinical trials have been less conclusive. A number of problems need to be solved if this application of cell biology is to become a part of vascular surgical practice.
血管外科的一个主要限制因素是，目前可用的人工血管在腹股沟韧带以下的通畅性无法与自体静脉相匹配。内皮细胞种植旨在形成一层内皮细胞内膜，而这层内膜在人工血管中原本是不存在的。这可以通过预防血栓形成以及抑制活化血小板释放与新生内膜增生发展相关的促有丝分裂原，来提高血管通畅性。实验证据支持了该技术的潜力，但临床试验的结论性较差。如果细胞生物学的这种应用要成为血管外科实践的一部分，还需要解决一些问题。
