Cohen P R, Talpaz M, Kurzrock R
Department of Dermatology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
J Clin Oncol. 1988 Dec;6(12):1887-97. doi: 10.1200/JCO.1988.6.12.1887.
Sweet's syndrome is an acute febrile neutrophilic dermatosis in which approximately 20% of the reported patients have an associated cancer. We review the 79 patients with malignancy-associated Sweet's syndrome documented in the world literature. The most common underlying neoplasm was acute myelogenous leukemia (AML). Lymphomas, chronic leukemias, myelomas, myelodysplastic syndromes, and a variety of solid tumors have also been observed. The onset of Sweet's syndrome either preceded or coincided with the discovery of a previously undiagnosed cancer in greater than 60% of malignancy-associated Sweet's syndrome patients. In contrast to patients with the idiopathic form of the disease, those with a malignancy often presented with more severe cutaneous lesions, cytopenias, and/or immature cells in the peripheral blood. Extracutaneous sites of involvement included the eyes, muscles and joints, kidneys, lungs, and liver. All the manifestations of Sweet's syndrome improved dramatically with corticosteroid therapy, regardless of the response of the associated neoplasm to tumor-directed therapy.
斯威特综合征是一种急性发热性嗜中性皮病，约20%的报告患者伴有癌症。我们回顾了世界文献中记录的79例与恶性肿瘤相关的斯威特综合征患者。最常见的潜在肿瘤是急性髓系白血病（AML）。也观察到淋巴瘤、慢性白血病、骨髓瘤、骨髓增生异常综合征以及多种实体瘤。在超过60%的与恶性肿瘤相关的斯威特综合征患者中，斯威特综合征的发作先于或与先前未诊断出的癌症的发现同时发生。与特发性疾病患者相比，患有恶性肿瘤的患者通常表现出更严重的皮肤病变、血细胞减少和/或外周血中的未成熟细胞。皮肤外受累部位包括眼睛、肌肉和关节、肾脏、肺和肝脏。无论相关肿瘤对肿瘤导向治疗的反应如何，斯威特综合征的所有表现用皮质类固醇治疗后均显著改善。
