接受加速超分割放化疗的非小细胞肺癌患者急性放射性食管炎的预测因素
Predictors of Acute Radiation Esophagitis in Non-small Cell Lung Cancer Patients Treated With Accelerated Hyperfractionated Chemoradiotherapy.
作者信息
Wada Kentaro, Kishi Noriko, Kanayama Naoyuki, Hirata Takero, Ueda Yoshihiro, Kawaguchi Yoshifumi, Morimoto Masahiro, Konishi Koji, Imamura Fumio, Ogawa Kazuhiko, Teshima Teruki
机构信息
Department of Radiation Oncology, Osaka International Cancer Institute Hospital, Osaka, Japan
Department of Radiation Oncology, Osaka International Cancer Institute Hospital, Osaka, Japan.
出版信息
Anticancer Res. 2019 Jan;39(1):491-497. doi: 10.21873/anticanres.13139.
BACKGROUND/AIM: To identify the clinical and dosimetric predictors of severe acute radiation esophagitis (RE) in patients with non-small cell lung cancer (NSCLC) treated with accelerated hyperfractionated concurrent chemoradiotherapy (AH-CCRT) with concomitant boost technique.
PATIENTS AND METHODS
A total of 159 patients who underwent AH-CCRT (64 Gy in 40 fractions twice daily) were retrospectively identified. Severe RE was designated as grade 3 or higher according to the Common Terminology Criteria for Adverse Events, version 4.0.
RESULTS
The incidence rate of grade 3 RE was 15.1% (24/159). The multivariate analysis that incorporated the Eastern Cooperative Oncology Group performance status (ECOG PS, ≥1 vs. 0) and the relative esophagus volume irradiated with at least 60 Gy (V) was optimal. Patients with a V of ≥15% had a 37.8% risk of grade 3 RE compared to a 6.1% risk among those with a V of <15%.
CONCLUSION
ECOG PS (≥1 vs. 0) and the V were found to be significant risk factors for severe RE in NSCLC patients who underwent AH-CCRT.
背景/目的：确定采用加速超分割同步放化疗（AH-CCRT）联合推量技术治疗的非小细胞肺癌（NSCLC）患者发生严重急性放射性食管炎（RE）的临床和剂量学预测因素。
患者与方法
回顾性纳入159例行AH-CCRT（40次分割，每日2次，共64 Gy）的患者。根据不良事件通用术语标准4.0版，将严重RE定义为3级或更高等级。
结果
3级RE的发生率为15.1%（24/159）。纳入东部肿瘤协作组体能状态（ECOG PS，≥1 vs. 0）和至少60 Gy照射的相对食管体积（V）的多因素分析最为理想。V≥15%的患者发生3级RE的风险为37.8%，而V<15%的患者风险为6.1%。
结论
ECOG PS（≥1 vs. 0）和V被发现是接受AH-CCRT的NSCLC患者发生严重RE的显著危险因素。
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