肺癌患者接受根治性或辅助放疗后的睡眠障碍。
Sleep Disturbances in Lung Cancer Patients Assigned to Definitive or Adjuvant Irradiation.
机构信息
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany;
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
出版信息
In Vivo. 2021 Nov-Dec;35(6):3333-3337. doi: 10.21873/invivo.12630.
BACKGROUND/AIM: A considerable number of patients with lung cancer are scheduled for definitive or adjuvant radiotherapy. Prevalence and potential risk factors of pre-radiotherapy sleep disturbances were evaluated.
PATIENTS AND METHODS
Nineteen factors were retrospectively investigated for associations with pre-radiotherapy sleep disturbances in 77 lung cancer patients. Factors included COVID-19 pandemic; age; gender; performance score; comorbidity index; history of another malignancy; distress score; number of emotional, physical or practical problems; patient's request for psychological support; histology; tumor stage; upfront surgery; chemotherapy; and type of radiotherapy.
RESULTS
Thirty-one patients (40.3%) reported sleep disturbances that were significantly associated with distress score 6-10 (p=0.019), ≥2 emotional problems (p=0.001), ≥5 physical problems (p<0.001), and request for psychological support (p=0.006). Trends were found for female gender (p=0.064) and stereotactic body radiation therapy (p=0.057).
CONCLUSION
Many lung cancer patients assigned to radiotherapy reported sleep disturbances. Risk factors can be used to identify patients in need of psychological support already before treatment.
背景/目的：相当数量的肺癌患者需要进行根治性或辅助性放疗。本研究评估了放疗前睡眠障碍的发生率和潜在的危险因素。
患者和方法
回顾性分析了 77 例肺癌患者的 19 个因素与放疗前睡眠障碍的关系。这些因素包括 COVID-19 大流行；年龄；性别；体力状况评分；合并症指数；是否有其他恶性肿瘤病史；痛苦评分；情绪、身体或实际问题的数量；患者对心理支持的需求；组织学类型；肿瘤分期；初始手术；化疗；以及放疗类型。
结果
31 例（40.3%）患者报告存在睡眠障碍，这些患者的痛苦评分（6-10 分）（p=0.019）、≥2 个情绪问题（p=0.001）、≥5 个身体问题（p<0.001）和对心理支持的需求（p=0.006）与睡眠障碍显著相关。女性（p=0.064）和立体定向体部放疗（SBRT）（p=0.057）与睡眠障碍存在趋势性相关。
结论
许多接受放疗的肺癌患者报告存在睡眠障碍。这些风险因素可用于在治疗前识别需要心理支持的患者。
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