Department of Surgery & Cancer, Academic Surgical Unit, Imperial College London, 10th Floor, QEQM Building, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
Obes Surg. 2019 Mar;29(3):1031-1039. doi: 10.1007/s11695-018-3501-8.
This study has analyzed results from registry-based population studies to assess the effect of bariatric surgery upon cancer incidence at a population level. Relevant studies were identified and meta-analysis was used to calculate pooled odds ratios (POR) for the incidence of cancer after bariatric surgery compared to controls. Eight population-based studies were included with 635,642 total patients. Bariatric surgery was associated with a significant reduction in overall cancer incidence (POR = 0.72; 95% CI 0.59 to 0.87; p = 0.0007) and incidence of obesity-related cancer (POR = 0.55; 95% CI 0.31 to 0.96; p = 0.04). Bariatric surgery was also protective for breast cancer development (POR = 0.50; 95% CI 0.25 to 0.99; p = 0.045). Bariatric surgery appears to be associated with a reduction in cancer incidence at a population-based level.
本研究通过基于注册的人群研究分析结果，评估了肥胖症手术对人群癌症发病率的影响。确定了相关研究，并采用荟萃分析计算了肥胖症手术与对照组相比后癌症发病率的合并优势比（POR）。共纳入 8 项基于人群的研究，总计 635642 名患者。肥胖症手术与总体癌症发病率的显著降低相关（POR=0.72；95%CI 0.59 至 0.87；p=0.0007）和肥胖相关癌症的发病率（POR=0.55；95%CI 0.31 至 0.96；p=0.04）。肥胖症手术对于乳腺癌的发展也具有保护作用（POR=0.50；95%CI 0.25 至 0.99；p=0.045）。肥胖症手术似乎与基于人群的癌症发病率降低有关。
