Ficarra G, Berson A M, Silverman S, Quivey J M, Lozada-Nur F, Sooy D D, Migliorati C A
Division of Oral Medicine, University of California, San Francisco.
Oral Surg Oral Med Oral Pathol. 1988 Nov;66(5):543-50. doi: 10.1016/0030-4220(88)90373-8.
Since our first description and profile of patients with Kaposi's sarcoma (KS) in 1984, the relative rate of KS in patients with the acquired immunodeficiency syndrome has dropped from 34% to 20%. However, the absolute number is increasing. The pathogenesis of KS is still obscure, and its interaction with the human immunodeficiency virus infection remains unclear. Cause of death is usually opportunistic infections in both endemic and epidemic KS. The most common intraoral site is the palate, which is involved in 95% of our cases. The oral cavity may be the only or first site of KS, and therefore, becomes important in the diagnosis. More than 20% of our current patient population had the oral cavity as the initial site of manifestation. Because of functional impairment, bleeding, pain, or cosmetic reasons, treatment is frequently required. There are many modalities used, including chemotherapy, radiation, and laser resection. Radiation appears to be a most effective and practical control measure for oral KS.
自1984年我们首次描述卡波西肉瘤（KS）患者并介绍其概况以来，获得性免疫缺陷综合征患者中KS的相对发病率已从34%降至20%。然而，绝对数量却在增加。KS的发病机制仍不清楚，其与人类免疫缺陷病毒感染的相互作用也仍不明确。在地方性和流行性KS中，死因通常都是机会性感染。最常见的口腔发病部位是腭部，在我们的病例中，95%的患者腭部受累。口腔可能是KS的唯一发病部位或首发部位，因此在诊断中具有重要意义。我们目前的患者群体中，超过20%是以口腔作为首发表现部位。由于功能障碍、出血、疼痛或美容原因，常常需要进行治疗。治疗方式有很多种，包括化疗、放疗和激光切除。放疗似乎是控制口腔KS最有效、最实用的措施。
