Kabani S, Cataldo E, Folkerth R, Delellis R A, Bhan I, Farren P, Neville T
Tufts University School of Dental Medicine, Boston, Mass.
Oral Surg Oral Med Oral Pathol. 1988 Nov;66(5):587-92. doi: 10.1016/0030-4220(88)90380-5.
In the oral cavity, differentiation between reactive and neoplastic lymphoproliferative lesions can, at times, be very difficult. We report an unusual case in which immunohistochemical findings were necessary to determine that the lesion was reactive despite the original interpretation of malignant lymphoma. The relationship of this lesion to atypical histiocytic granuloma, angiolymphoid hyperplasia with eosinophilia, and traumatic ulcerative granuloma with stromal eosinophilia is discussed and possible pathogenetic mechanisms are proposed. The value of immunohistochemistry in the diagnosis of extranodal lymphoproliferative lesions is emphasized.
在口腔中，有时区分反应性和肿瘤性淋巴增生性病变非常困难。我们报告了一例罕见病例，尽管最初诊断为恶性淋巴瘤，但仍需免疫组化结果来确定该病变为反应性。本文讨论了该病变与非典型组织细胞性肉芽肿、嗜酸性粒细胞增多性血管淋巴样增生及伴有间质嗜酸性粒细胞增多的创伤性溃疡性肉芽肿之间的关系，并提出了可能的发病机制。强调了免疫组化在结外淋巴增生性病变诊断中的价值。
