del Río E, Sánchez Yus E, Requena L, García Puente L, Vázquez Veiga H
Department of Dermatology, Hospital Universitario San Carlos, Madrid, Spain.
J Cutan Pathol. 1997 Jan;24(1):51-5. doi: 10.1111/j.1600-0560.1997.tb00786.x.
Although 2% to 10% of lymphomas present first in the oral cavity and lymphomas are the third most common oral malignancy, pseudolymphoma is a very infrequent problem within oral pathology. Two cases of oral pseudolymphoma are presented. Both were old persons with an infiltrative lesion on the oral mucosa that histologically showed a dense polymorphous infiltrate with some nuclear atypia that raised the problem of lymphoma versus pseudolymphoma. Both lesions disappeared with no relapse after 2-years' follow-up. Histologically, case 1 was mainly a lymphohistiocytic infiltrate whose histiocytic component showed nuclear features that mimicked Hodgkin's cells. In case 2, the infiltrate was mainly composed of histiocytes and eosinophils. The suspicion of malignancy here was a consequence of a high mitotic rate of histiocytes and of the large hyperchromatic nuclei of the intraepithelial lymphocytes. Similarities and differences with other pseudomalignant (lymphomatoid papulosis and atypical histiocytic granuloma) and inflammatory (traumatic ulcerative granuloma with stromal eosinophilia) disorders, as well as with some histiocytoses, are discussed. In the absence of a wider experience on this subject, an objective description of new cases seems appropriate.
尽管2%至10%的淋巴瘤最初表现于口腔，且淋巴瘤是口腔第三常见的恶性肿瘤，但假性淋巴瘤在口腔病理学中是一个非常罕见的问题。本文报告2例口腔假性淋巴瘤。两例均为老年患者，口腔黏膜有浸润性病变，组织学显示为密集的多形性浸润，伴有一些核异型性，这引发了淋巴瘤与假性淋巴瘤鉴别的问题。经过2年随访，两例病变均消失且无复发。组织学上，病例1主要为淋巴细胞 - 组织细胞浸润，其组织细胞成分显示出类似霍奇金细胞的核特征。病例2中，浸润主要由组织细胞和嗜酸性粒细胞组成。此处怀疑为恶性肿瘤是由于组织细胞有较高的有丝分裂率以及上皮内淋巴细胞有大的深染核。文中讨论了与其他假性恶性疾病（淋巴瘤样丘疹病和非典型组织细胞性肉芽肿）、炎症性疾病（伴有间质嗜酸性粒细胞增多的创伤性溃疡性肉芽肿）以及一些组织细胞增多症的异同。鉴于对此主题缺乏更广泛的经验，对新病例进行客观描述似乎是恰当的。
