Yao Yizhou, Wang Xuchao, Jiang Linhua, Shao Xinyu, Zhu Xinguo, He Songbing
Department of General Surgery, The First Affiliated Hospital of Soochow University.
Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Medicine (Baltimore). 2018 Dec;97(52):e13899. doi: 10.1097/MD.0000000000013899.
The study aims to assess the relationship between FoxM1 expression and clinicopathological parameters and prognosis of patients diagnosed with colorectal cancer (CRC) by summarizing the studies included.
PubMed, EMBASE, The Cochrane Library and other sources were searched for relative studies. Odds ratio (OR) and confidence interval (CI) were used to assess association between FoxM1 expression and clinical parameters and prognosis of CRC patients.
Eight studies were included in the final analysis, with 1149 CRC patients. The outcome revealed that expression of FoxM1 was associated with lymph node metastasis (OR = 0.33, 95%CI = 0.19-0.62, P < .001), distant metastasis (OR = 0.35, 95%CI = 0.24-0.46, P < .001) and tumor node metastasis (TNM) stage (OR = 0.45, 95%CI = 0.29-0.72, P < .001). Meanwhile, reduced FoxM1 expression indicated higher 5-year survival rate (OR = 0.38, 95%CI = 0.18-0.78, P = .01). Expression of FoxM1 was also increased obviously in CRC tissues (OR = 13.04, 95%CI = 4.07-41.71, P < .001).
This pooled analysis indicated that FoxM1 expression related to lymph node metastasis, distant metastasis, TNM stage and poor prognosis of the CRC patients.
本研究旨在通过总结纳入的研究，评估叉头框蛋白M1（FoxM1）表达与结直肠癌（CRC）患者临床病理参数及预后之间的关系。
检索了PubMed、EMBASE、考克兰图书馆等来源的相关研究。采用比值比（OR）和置信区间（CI）评估FoxM1表达与CRC患者临床参数及预后之间的关联。
最终分析纳入8项研究，共1149例CRC患者。结果显示，FoxM1表达与淋巴结转移（OR = 0.33，95%CI = 0.19 - 0.62，P <.001）、远处转移（OR = 0.35，95%CI = 0.24 - 0.46，P <.001）及肿瘤淋巴结转移（TNM）分期（OR = 0.45，95%CI = 0.29 - 0.72，P <.001）相关。同时，FoxM1表达降低表明5年生存率较高（OR = 0.38，95%CI = 0.18 - 0.78，P =.01）。FoxM1在CRC组织中的表达也明显升高（OR = 13.04，95%CI = 4.07 - 41.71，P <.001）。
这项汇总分析表明，FoxM1表达与CRC患者的淋巴结转移、远处转移、TNM分期及不良预后相关。
