Department of Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241000, China.
Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, No.242 Guangji Road, Suzhou, 215006, Jiangsu Province, China.
Sci Rep. 2020 Nov 19;10(1):20160. doi: 10.1038/s41598-020-77182-z.
Colorectal carcinoma (CRC) is one of the most common malignancies with a dismal 5-year survival rate. Our recent study indicated that Rab1A expression was closely related to GLI1 expression. A previous study shows that aberrant overexpression of GLI1 promotes colorectal cancer metastasis via FoxM1 overexpression. However, the potential correlation between Rab1A and FoxM1 in CRC remains elusive. Immunohistochemistry was performed to investigate the association of the expression of Rab1A and FoxM1 and to determine the prognosis in 135 CRC tissue and adjacent normal tissues. Using Oncomine datasets, we found that Rab1A and FoxM1 mRNA were obviously upregulated in CRC tissues compared to normal tissues. Additionally, the expression of Rab1A and FoxM1 was significantly higher in CRC tissues than that in normal tissues. Rab1A expression was positively correlated with FoxM1 expression in CRC, especially in TNM stage III. In addition, Rab1A and FoxM1 overexpression was found to be significantly correlated with poor prognosis in CRC patients. Besides, both high expression of Rab1A and FoxM1 led to a worse prognosis than anyone low group, and both low expression of Rab1A and FoxM1 had a better prognosis than the anyone low group. Therefore, Rab1A and FoxM1 play crucial roles and could be used as clinical biomarkers in CRC.
结直肠癌（CRC）是最常见的恶性肿瘤之一，其 5 年生存率较差。我们最近的研究表明，Rab1A 的表达与 GLI1 的表达密切相关。先前的研究表明，GLI1 的异常过表达通过 FoxM1 的过表达促进结直肠癌细胞转移。然而，Rab1A 与 CRC 中 FoxM1 之间的潜在相关性仍不清楚。免疫组织化学分析用于研究 Rab1A 和 FoxM1 的表达与 135 例 CRC 组织和相邻正常组织中预后的关系。通过 Oncomine 数据集，我们发现 Rab1A 和 FoxM1mRNA 在 CRC 组织中明显高于正常组织。此外，Rab1A 和 FoxM1 的表达在 CRC 组织中明显高于正常组织。Rab1A 在 CRC 中的表达与 FoxM1 的表达呈正相关，尤其是在 TNM Ⅲ期。此外，Rab1A 和 FoxM1 的过表达与 CRC 患者的不良预后显著相关。此外，Rab1A 和 FoxM1 的高表达均比任何低表达组的预后差，而 Rab1A 和 FoxM1 的低表达均比任何低表达组的预后好。因此，Rab1A 和 FoxM1 发挥着重要作用，可作为 CRC 的临床生物标志物。
