From the Laboratory of Structural Neurobiology, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
J Biol Chem. 2018 Dec 28;293(52):20008-20009. doi: 10.1074/jbc.H118.006869.
Magnesium homeostasis relies on transporters like the CNNM family, but little information on these proteins' structure and regulation limits our understanding of their biology and functions in disease. New characterization of a conserved cytoplasmic domain now confirms the presence of a self-liganded architecture that is indispensable for Mg efflux and suggests a possible role for a dimeric assembly.
镁离子稳态依赖于像 CNNM 家族这样的转运蛋白，但这些蛋白质的结构和调节方面的信息有限，限制了我们对它们在疾病中的生物学和功能的理解。对一个保守的细胞质结构域的新特性分析，现在证实了存在一种自我配体的结构，这种结构对于镁离子外排是必不可少的，并暗示了二聚体组装的可能作用。
