Vetrano Davide L, Palmer Katie M, Galluzzo Lucia, Giampaoli Simona, Marengoni Alessandra, Bernabei Roberto, Onder Graziano
Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Department of Geriatrics, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
BMJ Open. 2018 Dec 28;8(12):e024406. doi: 10.1136/bmjopen-2018-024406.
To review the association between hypertension and frailty in observational studies.
A systematic review of the PubMed, Web of Science and Embase databases was performed. A meta-analysis was performed if at least three studies used the same definition of frailty and a dichotomous definition of hypertension.
SETTING, PARTICIPANTS AND MEASURES: Studies providing information on the association between frailty and hypertension in adult persons, regardless of the study setting, study design or definition of hypertension and frailty were included.
Among the initial 964 articles identified, 27 were included in the review. Four longitudinal studies examined the incidence of frailty according to baseline hypertension status, providing conflicting results. Twenty-three studies assessed the cross-sectional association between frailty and hypertension: 13 of them reported a significantly higher prevalence of frailty in hypertensive participants and 10 found no significant association. The pooled prevalence of hypertension in frail individuals was 72% (95% CI 66% to 79%) and the pooled prevalence of frailty in individuals with hypertension was 14% (95% CI 12% to 17%). Five studies, including a total of 7656 participants, reported estimates for the association between frailty and hypertension (pooled OR 1.33; 95% CI 0.94 to 1.89).
Frailty is common in persons with hypertension. Given the possible influence of frailty on the risk-benefit ratio of treatment for hypertension and its high prevalence, it is important to assess the presence of this condition in persons with hypertension.
CRD42017058303.
回顾观察性研究中高血压与衰弱之间的关联。
对PubMed、科学网和Embase数据库进行系统综述。如果至少三项研究使用相同的衰弱定义和高血压二分法定义，则进行荟萃分析。
设置、参与者和测量：纳入提供有关成年人衰弱与高血压之间关联信息的研究，无论研究设置、研究设计或高血压与衰弱的定义如何。
在最初识别出的964篇文章中，27篇被纳入综述。四项纵向研究根据基线高血压状态检查了衰弱的发生率，结果相互矛盾。二十三项研究评估了衰弱与高血压之间的横断面关联：其中13项报告高血压参与者中衰弱的患病率显著更高，10项未发现显著关联。衰弱个体中高血压的合并患病率为72%（95%CI 66%至79%），高血压个体中衰弱的合并患病率为14%（95%CI 12%至17%）。五项研究，共7656名参与者报告了衰弱与高血压之间关联的估计值（合并OR 1.33；95%CI 0.94至1.89）。
衰弱在高血压患者中很常见。鉴于衰弱可能对高血压治疗的风险效益比产生影响且其患病率较高，评估高血压患者中这种情况的存在很重要。
CRD42017058303。
