Abooshahab R, Niyazi E, Yaghmaie P, Ghadaksaz H G, Hedayati M
Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.
Department of Biology, Faculty of Basic Sciences, Science Research Branch of Islamic Azad University, Tehran 1477893855, Iran.
Exp Oncol. 2018 Dec;40(4):299-302.
Adipokines are the proteins secreted from adipose tissue and play an important role in the control of metabolism. Dipeptidyl peptidase-4 (DPP4) is a novel adipokine with different biological role. As indicated by various studies, serum levels of DPP4 had been associated with body mass index (BMI), insulin resistance, metabolic syndrome and malignancy. The aim of this study was to assess the serum levels of DPP4 in patients with medullary thyroid cancer (MTC) in comparison with these in the control group.
This study was performed on 45 MTC patients (24 females and 21 males) and 45 healthy controls (21 females and 24 males). DPP4 and insulin serum levels were measured by ELISA, fasting glucose serum levels by enzyme-calorimetric method and insulin resistance index (HOMA-IR) by calculation using relevant equation. BMI (kg/m2) was also calculated.
Our data did not demonstrate a significant difference between serum DPP4 levels in MTC and healthy group (41.06 ± 22.08 ng/ml vs 39.94 ± 20.77 ng/ml, p > 0.05). Additionally, no significant difference was found in serum insulin and HOMA-IR concentrations between MTC patients and the controls (p > 0.05).
This study suggests that the fluctuation in the levels of DPP4 does not play an important role in prognosis, early detection and diagnosis of MTC. Furthermore, higher levels of DPP4 cannot be considered as a risk factor for MTC.
脂肪因子是由脂肪组织分泌的蛋白质，在代谢控制中发挥重要作用。二肽基肽酶4（DPP4）是一种具有不同生物学作用的新型脂肪因子。各种研究表明，DPP4的血清水平与体重指数（BMI）、胰岛素抵抗、代谢综合征及恶性肿瘤有关。本研究的目的是评估甲状腺髓样癌（MTC）患者血清DPP4水平，并与对照组进行比较。
本研究对45例MTC患者（24例女性和21例男性）和45例健康对照者（21例女性和24例男性）进行。采用酶联免疫吸附测定法（ELISA）检测DPP4和胰岛素血清水平，采用酶比色法检测空腹血糖血清水平，并通过相关公式计算胰岛素抵抗指数（HOMA-IR）。同时计算BMI（kg/m²）。
我们的数据显示，MTC组和健康组血清DPP4水平无显著差异（41.06±22.08 ng/ml对39.94±20.77 ng/ml，p>0.05）。此外，MTC患者与对照组之间血清胰岛素和HOMA-IR浓度也无显著差异（p>0.05）。
本研究表明，DPP4水平的波动在MTC的预后、早期检测和诊断中不起重要作用。此外，较高的DPP4水平不能被视为MTC的危险因素。
