Centre de Recherche Cardio-Thoracique de Bordeaux (INSERM U1045), Université de Bordeaux, Bordeaux F-33076 Cedex, France.
Department of Chemistry and Biotechnology, Division of Gene Technology, Tallinn University of Technology, 12618 Tallinn, Estonia.
Biochim Biophys Acta Mol Cell Res. 2019 Apr;1866(4):545-553. doi: 10.1016/j.bbamcr.2018.12.009. Epub 2018 Dec 27.
Extensive in vitro studies have described podosomes as actin-based structures at the plasma membrane, connecting the cell with its extracellular matrix and endowed with multiple capabilities. Contractile actin-myosin cables assemble them into a network that constitutes a multifaceted cellular superstructure taking different forms - with common characteristics - but manifesting different properties depending on the context of study. Their morphology and their role in cell functioning and behavior are therefore now apprehended in in vivo or in vitro situations relevant to physiological processes. We focus here on three of them, namely: macrophage migration, antigen presentation by dendritic cells and endothelial cell sprouting during angiogenesis to highlight the characteristics of podosomes and their functioning shaped by the microenvironment.
大量的体外研究已经描述了足突是质膜上的基于肌动蛋白的结构，将细胞与其细胞外基质连接起来，并具有多种功能。收缩性肌动蛋白-肌球蛋白电缆将它们组装成一个网络，构成一个多方面的细胞超结构，具有共同的特征，但表现出不同的特性，这取决于研究的背景。因此，现在在与生理过程相关的体内或体外情况下，它们的形态及其在细胞功能和行为中的作用都可以被理解。我们在这里重点关注其中的三个方面，即：巨噬细胞迁移、树突状细胞的抗原呈递和血管生成过程中的内皮细胞出芽，以突出足突的特征及其受微环境影响的功能。
