Rouhani Borzu, Ghaderian Sayyed Mohammad Hossein, Salehi Zivar
Department of Genetic, Faculty of Science, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hum Antibodies. 2019;27(2):99-104. doi: 10.3233/HAB-180353.
Conventional coronary artery disease (CAD) is the leading cause of morbidity and mortality in the general population. In recent years, multiple CAD promising risk factors have been reported and used for risk stratification. Lipoprotein(a) [LPA] concentration in plasma was shown associated with CAD risk and LPA genetic variants in different ethnic groups remains less clear.
We obtained data from 100 affected patients with established CAD and 100 healthy controls. We tested Body mass index (BMI), total cholesterol level (TC), systolic blood pressure (SBP), diastolic blood pressure (DBP), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), fasting blood sugar (FBS) and two LPA (rs10455872 and rs3798220 SNPs) between cases and healthy controls. TaqMan SNP genotyping assays were performed to detect variants.
Obtained data for BMI, TC, SBP, DBP, and LDL have significantly difference between two groups. Individually, the single SNPs were not associated with CAD in different analysis models. Also there was no significant difference in the incidence of CAD among cases carrying different genotypes of the two variants in LPA with p> 0.05.
In this study patients with CAD, lipoprotein(a) concentrations and genetic variants showed no associations and we conclude that these variables are not useful risk factors to predict progression to disease is Iranian population. However, the prevalence and association of LPA SNPs with size of LPA and isoforms are highly variable and genetic background-specific.
Our data did not indicate a relationship between genomic LPA variants (rs10455872 and rs3798220) and subsequent cardiovascular events in Iranian CAD patients. We did not confirm the association of the theses SNPs with CAD in our samples of Iranian patients. For the studied variants, our finding is consistent with reports which showed the lack of this genetic association in other populations.
传统冠状动脉疾病（CAD）是普通人群发病和死亡的主要原因。近年来，已报道了多种有前景的CAD风险因素并用于风险分层。血浆中脂蛋白(a)[Lp(a)]浓度与CAD风险相关，而不同种族群体中Lp(a)基因变异情况仍不太清楚。
我们获取了100例确诊CAD患者和100例健康对照的数据。我们检测了病例组和健康对照组之间的体重指数（BMI）、总胆固醇水平（TC）、收缩压（SBP）、舒张压（DBP）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、甘油三酯（TG）、空腹血糖（FBS）以及两个Lp(a)（rs10455872和rs3798220单核苷酸多态性）。采用TaqMan SNP基因分型检测法检测变异。
BMI、TC、SBP、DBP和LDL的所得数据在两组之间有显著差异。单独来看，在不同分析模型中，单个单核苷酸多态性与CAD无关。而且，携带Lp(a)两个变异不同基因型的病例中CAD发病率也无显著差异，p>0.05。
在本研究的CAD患者中，脂蛋白(a)浓度和基因变异未显示出相关性，我们得出结论，在伊朗人群中，这些变量并非预测疾病进展的有用风险因素。然而，Lp(a)单核苷酸多态性的患病率及其与Lp(a)大小和异构体的相关性具有高度变异性且具有基因背景特异性。
我们的数据未表明伊朗CAD患者基因组Lp(a)变异（rs10455872和rs3798220）与随后的心血管事件之间存在关联。在我们的伊朗患者样本中，我们未证实这些单核苷酸多态性与CAD有关联。对于所研究的变异，我们的发现与其他人群中缺乏这种基因关联的报道一致。
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