Graduate School, Tianjin Medical University, Tianjin, China.
Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
J Int Med Res. 2020 Oct;48(10):300060520965353. doi: 10.1177/0300060520965353.
To investigate the relationship between lipoprotein(a) gene () polymorphisms and calcific aortic valve disease (CAVD) and coronary heart disease (CHD) in Han Chinese.
A total of 148 patients were recruited (n = 71 with CAVD and n = 77 with CHD) based on a diagnosis achieved using color Doppler echocardiography, coronary angiography, or computed tomography angiography. Seventy-one control individuals without CAVD or CHD were also recruited. Biomarkers including levels of lipoprotein(a) [Lp(a)], low-density lipoprotein and high-density lipoprotein cholesterol, apolipoprotein A1, and apolipoprotein B were tested. polymorphisms rs10455872, rs6415084, rs3798221, and rs7770628 were analyzed using SNaPshot SNP.
Lp(a) levels were significantly higher in CAVD and CHD groups compared with controls. There was no significant difference in the allelic frequency distribution of rs3798221, rs7770628, or rs6415084 between CHD, CAVD, and control groups. Linear regression showed that rs3798221, rs7770628, and rs6415084 were associated with increased Lp(a) concentrations. Two CAVD patients among the 219 participants carried AG minor alleles at rs10455872, while the remainder carried AA minor alleles.
rs3798221, rs6415084, and rs7770628 polymorphisms within are associated with higher Lp(a) plasma levels, which correlate with increased CAVD and CHD risks.
探讨载脂蛋白(a)基因()多态性与汉族人群钙化性主动脉瓣疾病（CAVD）和冠心病（CHD）的关系。
根据彩色多普勒超声心动图、冠状动脉造影或计算机断层血管造影检查的诊断，共纳入 148 例患者（n=71 例 CAVD 患者和 n=77 例 CHD 患者）。还纳入了 71 名无 CAVD 或 CHD 的对照组个体。检测了包括脂蛋白(a)[Lp(a)]、低密度脂蛋白和高密度脂蛋白胆固醇、载脂蛋白 A1 和载脂蛋白 B 在内的生物标志物。采用 SNaPshot SNP 分析 多态性 rs10455872、rs6415084、rs3798221 和 rs7770628。
与对照组相比，CAVD 和 CHD 组的 Lp(a)水平明显升高。CHD、CAVD 和对照组之间 rs3798221、rs7770628 或 rs6415084 的等位基因频率分布无显著差异。线性回归显示 rs3798221、rs7770628 和 rs6415084 与 Lp(a)浓度升高相关。在 219 名参与者中，有 2 名 CAVD 患者携带 rs10455872 的 AG 小等位基因，其余患者携带 AA 小等位基因。
内的 rs3798221、rs6415084 和 rs7770628 多态性与较高的 Lp(a)血浆水平相关，而 Lp(a)水平升高与 CAVD 和 CHD 风险增加相关。
