伊朗耐碳青霉烯类肺炎克雷伯菌：一项系统评价与Meta分析
Carbapenem-Resistant Klebsiella Pneumoniae in Iran: a Systematic Review and Meta-Analysis.
作者信息
Vaez Hamid, Sahebkar Amirhossein, Khademi Farzad
机构信息
a Department of Microbiology, School of Medicine , Zabol University of Medical Sciences , Zabol , Iran.
b Neurogenic Inflammation Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.
出版信息
J Chemother. 2019 Feb;31(1):1-8. doi: 10.1080/1120009X.2018.1533266. Epub 2018 Dec 30.
The global emergence and dissemination of carbapenem-resistant (CR)-Klebsiella pneumoniae is an important healthcare concern owing to the limited therapeutic options that are available. The aim of the present study was to evaluate the prevalence of CR K. pneumoniae in different parts of Iran. A comprehensive literature search was performed in national and international databases. After applying predefined inclusion and exclusion criteria, 36 articles reporting prevalence of CR K. pneumoniae were collected. The pooled prevalence of CR K. pneumoniae was estimated to be 11.3% (95% CI: 0.084-0.15). The highest and lowest prevalence rates of CR K. pneumoniae were in Isfahan 58% (95% CI: 0.48-0.67) and Tehran 0.004 (95% CI: 0.00-0.05), respectively. The highest and lowest resistance rates were seen against aztreonam (55%, 95% CI: 0.48-0.62) and amikacin (23%, (95% CI: 0.17-0.29), respectively. The findings of the present study revealed that the prevalence of CR K. pneumoniae is alarmingly high in the majority of Iranian hospitals.
耐碳青霉烯类肺炎克雷伯菌在全球的出现和传播是一个重要的医疗问题，因为可用的治疗选择有限。本研究的目的是评估伊朗不同地区耐碳青霉烯类肺炎克雷伯菌的流行情况。在国内和国际数据库中进行了全面的文献检索。在应用预定义的纳入和排除标准后，收集了36篇报告耐碳青霉烯类肺炎克雷伯菌流行情况的文章。耐碳青霉烯类肺炎克雷伯菌的合并流行率估计为11.3%（95%可信区间：0.084 - 0.15）。耐碳青霉烯类肺炎克雷伯菌的最高和最低流行率分别在伊斯法罕为58%（95%可信区间：0.48 - 0.67）和德黑兰为0.004（95%可信区间：0.00 - 0.05）。最高和最低耐药率分别见于氨曲南（55%，95%可信区间：0.48 - 0.62）和阿米卡星（23%，95%可信区间：0.17 - 0.29）。本研究结果显示，在大多数伊朗医院中，耐碳青霉烯类肺炎克雷伯菌的流行率高得惊人。
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