耐碳青霉烯类抗生素的 和 的流行率和机制：来自伊朗的横断面研究的系统评价和荟萃分析。
Prevalence and Mechanisms of Carbapenem Resistance in and : A Systematic Review and Meta-Analysis of Cross-Sectional Studies from Iran.
机构信息
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA.
出版信息
Microb Drug Resist. 2020 Dec;26(12):1491-1502. doi: 10.1089/mdr.2019.0440. Epub 2020 Apr 28.
Carbapenem-resistant Enterobacteriaceae (CRE) represents an urgent threat worldwide. We aimed to investigate the frequency of carbapenem-resistant and in Iran. PubMed/Medline, Embase, Scopus, Web of Sciences, and Iranian databases were searched to find potentially relevant articles. Statistical analyses were performed using STATA version 14. Forty-nine studies fulfilled the inclusion criteria. The pooled rates of resistance to carbapenem in and were 24.0% (95% confidence interval [CI] 18.0-31.0) and 5.0% (95% CI 2.0-8.0), respectively. gene was the most common cause of carbapenem resistance in and CRE is prevalent in Iran, which confers the importance of strength prevention and control measures.
碳青霉烯类耐药肠杆菌科（CRE）在全球范围内构成了紧迫威胁。本研究旨在调查伊朗碳青霉烯类耐药 和 的流行率。通过检索 PubMed/Medline、Embase、Scopus、Web of Sciences 和伊朗数据库，以寻找可能相关的文章。采用 STATA 版本 14 进行统计学分析。49 项研究符合纳入标准。 和 对碳青霉烯类药物的耐药率分别为 24.0%（95%置信区间[CI] 18.0-31.0）和 5.0%（95%CI 2.0-8.0）。 在 和 中， 基因是导致碳青霉烯类耐药的最常见原因。CRE 在伊朗普遍存在，这凸显了加强预防和控制措施的重要性。
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