Procopie I, Anușca D N, Onțică V, Mureșan R
Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.
Department of Orthopedics, Emergency County Hospital, Brăila, Romania.
Curr Health Sci J. 2017 Apr-Jun;43(2):153-158. doi: 10.12865/CHSJ.43.02.08. Epub 2017 Jun 29.
Osteoarticular tuberculosis (OATB) is a secondary chronic infection with paubacillary bacillus Koch (BK) that has bone and joint interest. Today in Romania, tuberculosis is a primary public health problem, according to World Health Organization (WHO) in 2015 alone, there have been 10.4 million new cases of tuberculosis (TB) in the world, of which 15.195 in Romania. Pulmonary and extrapulmonary tuberculosis, especially the osteoarticular form, with multiple outbreaks should of had a minimal impact, but because of the multiple characteristics such as: epidemiological, geographic, associated diseases, diagnosis capacity, therapeutic options, gene pool and racial evolutiv traits, the disease spreading and management in both developed and underdeveloped countries, the TB infection has seen an increase in the number of cases (e.g. Africa and Asia). Today there is a fecundity upsurge of BK infection, especially pronounced in low income populations, country side people being the most affected. There are multiple breakthroughs in the understanding of Mycobacterium tuberculosis physiopathology. This fact offers us a modern and genetically guided approach in the diagnosis, evolutive patterns and treatment involving the OATB.
骨关节结核（OATB）是一种由结核杆菌（BK）引起的继发性慢性感染，累及骨骼和关节。如今在罗马尼亚，结核病是一个主要的公共卫生问题，根据世界卫生组织（WHO）的数据，仅在2015年，全球就有1040万例新发结核病病例，其中罗马尼亚有15195例。肺及肺外结核，尤其是骨关节型，多次爆发本应影响最小，但由于其流行病学、地理、相关疾病、诊断能力、治疗选择、基因库和种族进化特征等多种特性，在发达国家和不发达国家，结核病感染的病例数都有所增加（如非洲和亚洲）。如今，BK感染的发生率急剧上升，在低收入人群中尤为明显，农村人口受影响最大。在对结核分枝杆菌生理病理学的认识上有多个突破。这一事实为我们提供了一种现代的、基于基因指导的方法来诊断、了解其演变模式并治疗骨关节结核。
