Coteanu Catalina, Gusti Alice, Coteanu M F, Gusti Simona
Department of Clinical Laboratory, Clinical County Hospital of Craiova.
Department of Physiology, Faculty of Physical Education and Sports, University of Craiova.
Curr Health Sci J. 2017 Oct-Dec;43(4):351-354. doi: 10.12865/CHSJ.43.04.11. Epub 2017 Dec 28.
In the last 30 years there has been a long way in what concerns the ability to test and diagnose cognitive disorders. On the other hand, it is more and more obvious the necessity to discover new parameters, which can clearly witness the passage from the physiological state of aging to a cognitive impairment in various stages (ranging from mild cognitive impairment to severe dementia). Bringing together all the clinical, paraclinical and neuropsychological data trying to discover the missing link between metabolic disorders, chronic inflammatory changes, progression of atherosclerosis, and the appearance of cognitive disorders, remains an extremely attractive and challenging field of research. By this study, we observed that there is a slight supremacy of the amnestic-MCI in patients with metabolic syndrome, without being able to extract statistically significant data. The interesting data obtained in this study emphasized the connection between the triglycerides/HDL-cholesterol ratio and the presence of the amnestic-MCI subtypes in patients with metabolic syndrome. The data obtained led to the conclusion that an increase in diastolic blood pressure in older people is a prediction factor for cognitive decline.
在过去30年里，在认知障碍的检测和诊断能力方面已经取得了长足的进步。另一方面，越来越明显的是，有必要发现新的参数，这些参数能够清晰地见证从生理衰老状态到不同阶段（从轻度认知障碍到重度痴呆）认知障碍的转变。整合所有临床、辅助临床和神经心理学数据，试图找出代谢紊乱、慢性炎症变化、动脉粥样硬化进展与认知障碍出现之间缺失的联系，仍然是一个极具吸引力和挑战性的研究领域。通过这项研究，我们观察到代谢综合征患者中遗忘型轻度认知障碍略占优势，但未能得出具有统计学意义的数据。本研究中获得的有趣数据强调了代谢综合征患者甘油三酯/高密度脂蛋白胆固醇比值与遗忘型轻度认知障碍亚型存在之间的联系。所得数据得出结论：老年人舒张压升高是认知衰退的一个预测因素。
