Université Paris 13, Sorbonne Paris Cité, Research Unit on Nutritional Epidemiology, U1153 Inserm/Inra/Cnam/Universite Paris 13, Centre de Recherche en Epidemiologies et Biostatistiques Sorbonne Paris Cite, UFR SMBH, 74, rue Marcel Cachin, Bobigny Cedex 93017, France.
Age Ageing. 2015 Jul;44(4):648-54. doi: 10.1093/ageing/afv053. Epub 2015 Apr 26.
longitudinal data as regards the link between the cumulative effect of cardiometabolic disorders and cognition are relatively scant and heterogeneous.
we examined the cross-time associations of MetS status with cognitive performance in ageing adults.
using data from the French SU.VI.MAX cohort, we studied 2,788 adults. The presence of abdominal obesity, hyperglycaemia, dyslipidaemia and elevated blood pressure was clinically evaluated in 1994-96. Cognitive performance was assessed after a mean of 13 years via a battery of six validated instruments. The standardised individual test scores were summed up to provide a composite cognitive performance measure; principal component analysis was performed to define performance scores on verbal memory and executive functioning. Associations between MetS and subsequent cognitive performance were examined via ANCOVA, providing estimates of mean difference and corresponding 95% confidence intervals (CI).
MetS status at midlife was not associated with subsequent cognitive function. However, a 1-unit increase in the number of cardiometabolic disorders present was associated with a decrease in the composite cognitive score (mean difference = -0.36; 95% CI: -0.68, -0.05). Significant associations were also found with several cardiometabolic disorders (hyperglycaemia, central obesity and dyslipidaemia) and specific cognitive domains.
this study supports the existence of a cross-time, cumulative effect of cardiometabolic disorders present at midlife and subsequent cognitive performance. Given the worldwide population ageing and the increase in MetS prevalence, there is an urgent need for recommendations as regards cognitive ageing.
关于代谢综合征（Metabolic Syndrome，MetS）与认知之间累积效应的纵向数据相对较少且存在异质性。
我们研究了代谢综合征状态与老年成年人认知表现之间的跨时间关联。
利用法国 SU.VI.MAX 队列的数据，我们研究了 2788 名成年人。1994-1996 年，临床评估了腹型肥胖、高血糖、血脂异常和血压升高的情况。在平均 13 年后，使用一套六项经过验证的工具评估认知表现。将标准化的个体测试分数相加，提供综合认知表现衡量标准；进行主成分分析，定义言语记忆和执行功能的表现分数。通过方差分析（ANCOVA）检查代谢综合征与随后认知表现之间的关联，提供平均差异估计值及其相应的 95%置信区间（CI）。
中年时期的代谢综合征状态与随后的认知功能无关。然而，存在的心血管代谢疾病数量每增加一个单位，综合认知评分就会降低（平均差异=-0.36；95%CI：-0.68，-0.05）。与几种心血管代谢疾病（高血糖、中心性肥胖和血脂异常）和特定认知领域也存在显著关联。
这项研究支持中年时期存在的心血管代谢疾病及其随后认知表现之间存在跨时间、累积效应。考虑到全球人口老龄化和代谢综合征患病率的增加，迫切需要有关认知老化的建议。
