Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Biomed Pharmacother. 2019 Mar;111:568-578. doi: 10.1016/j.biopha.2018.12.054. Epub 2018 Dec 29.
Diabetes is one of the most chronic and widespread diseases causing the damages to the male reproductive system. Nowadays, several studies have been performed to show the role of phenolic compounds in reducing the complications of diabetes. Carvacrol is a phenolic monoterpene which has been shown to have much therapeutic efficacy in various diseases.
Thirty-two adult male Wistar rats (n = 8 in each group) were used in this experimental study. The induction of diabetes was performed using a single intraperitoneal (IP) injection of STZ (50 mg/kg). Rats were assigned into the following groups: control group, diabetic group, diabetic group daily fed with carvacrol at a dose of 75 mg/kg for 8 weeks, and the control group daily fed with carvacrol at a dose of 75 mg/kg for 8 weeks.
Treatment with carvacrol significantly improved the histological morphology of the testis, reduced the tissue activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes, and diminished the elevated levels of tissue malondialdehyde (MDA) (p < 0.05). Moreover, our results showed that carvacrol significantly decreased Bax and increased Bcl-2 at the levels of gene and protein expression. It also significantly (p < 0.05) reduced the rate of germ cell apoptosis.
It seems that the treatment with carvacrol mitigates testicular tissue damage in diabetic rats possibly through its antioxidant properties.
糖尿病是一种最常见的慢性疾病,可导致男性生殖系统受损。如今,已有多项研究表明酚类化合物在降低糖尿病并发症方面的作用。香芹酚是一种酚类单萜,已被证明在多种疾病中有很好的治疗效果。
本实验研究使用了 32 只成年雄性 Wistar 大鼠(每组 8 只)。通过单次腹腔(IP)注射 STZ(50mg/kg)诱导糖尿病。大鼠被分为以下几组:对照组、糖尿病组、糖尿病组每天给予香芹酚 75mg/kg 治疗 8 周,以及对照组每天给予香芹酚 75mg/kg 治疗 8 周。
香芹酚治疗显著改善了睾丸的组织形态学,降低了组织中超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GPx)酶的活性,并降低了组织丙二醛(MDA)的升高水平(p<0.05)。此外,我们的结果表明,香芹酚显著降低了 Bax 的基因和蛋白表达水平,同时增加了 Bcl-2 的水平。它还显著(p<0.05)降低了生精细胞凋亡的比率。
香芹酚治疗可能通过其抗氧化特性减轻糖尿病大鼠的睾丸组织损伤。