阻塞性睡眠呼吸暂停治疗、慢波活动与淀粉样β。
Obstructive sleep apnea treatment, slow wave activity, and amyloid-β.
机构信息
Department of Neurology, Washington University, Saint Louis, MO.
Hope Center for Neurological Disorders, Washington University, Saint Louis, MO.
出版信息
Ann Neurol. 2019 Feb;85(2):291-295. doi: 10.1002/ana.25408. Epub 2019 Jan 17.
Abstract
Obstructive sleep apnea (OSA) increases risk of dementia, a relationship that may be mediated by amyloid-β (Aβ) and downstream Alzheimer disease pathology. We previously showed that OSA may impair Aβ clearance and affect the relationship between slow wave activity (SWA) and Aβ. In this study, SWA and CSF Aβ were measured in participants with OSA before and 1 to 4 months after treatment. OSA treatment increased SWA, and SWA was significantly correlated with lower Aβ after treatment. Greater improvement in OSA was associated with greater decreases in Aβ. We propose a model whereby OSA treatment may affect both Aβ release and clearance. Ann Neurol 2018 ANN NEUROL 2019;85:291-295.
摘要
阻塞性睡眠呼吸暂停（OSA）会增加痴呆的风险，这种关系可能是由淀粉样蛋白-β（Aβ）和下游阿尔茨海默病病理介导的。我们之前的研究表明，OSA 可能会损害 Aβ 的清除，并影响慢波活动（SWA）与 Aβ 之间的关系。在这项研究中，我们在 OSA 患者接受治疗前和治疗后 1 至 4 个月测量了 SWA 和 CSF Aβ。OSA 治疗增加了 SWA，并且 SWA 与治疗后 Aβ 降低显著相关。OSA 改善程度越大，Aβ 降低幅度越大。我们提出了一个模型，其中 OSA 治疗可能会影响 Aβ 的释放和清除。Ann Neurol 2018 ANN NEUROL 2019;85:291-295.
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