Chair and Department of Internal Diseases, Medical University of Lublin, Lublin, Poland.
1st Military Hospital in Lublin, Department of Internal Medicine, Lublin, Poland.
PLoS One. 2019 Sep 5;14(9):e0221255. doi: 10.1371/journal.pone.0221255. eCollection 2019.
Amyloid-β 1-40 (Aβ 1-40) and amyloid-β 1-42 (Aβ 1-42) are the proteins known to be involved in the pathogenesis of Alzheimer's disease (AD)-the most common cause of dementia in the elderly. Hypoxia is suspected to be one of conditions associated with Aβ plasma level increase. A common reason of hypoxia is obstructive sleep apnea (OSA), characterized by recurrent episodes of apnea.
The aim of the study was to evaluate plasma Aβ 1-40 and Aβ 1-42 concentrations in patients with OSA.
Patients with suspected OSA (n = 112) underwent polygraphic examinations Patients with confirmed OSA (n = 81) showed apnea/hypopnea index greater than or equal to 5. Mild and moderate form of the disease was defined when AHI was 5-30 (n = 38, OSA+), severe-when AHI was >30 (n = 43, OSA++). Individuals with AHI<5 (n = 31) served as control group (OSA-).
Aβ 1-40 concentrations in OSA++ (191.1 pg/ml) group was significantly (p<0.05) higher compared with OSA- (76.9 pg/ml) and OSA+ (159.4 pg/ml) and correlated with selected parameters of hypoxemia severity. There were no differences in Aβ 1-42 concentration between the groups.
In patients with severe OSA Aβ 1-40 plasma concentrations are significantly higher compared with OSA- and OSA+ and seem to be related to hypoxia severity, which may indicate increased risk of AD development in this group of patients.
淀粉样蛋白β 1-40（Aβ 1-40）和淀粉样蛋白β 1-42（Aβ 1-42）是已知与阿尔茨海默病（AD）发病机制有关的蛋白质，AD 是老年人最常见的痴呆症病因。缺氧被怀疑是导致 Aβ 血浆水平升高的原因之一。缺氧的一个常见原因是阻塞性睡眠呼吸暂停（OSA），其特征是反复发生呼吸暂停。
本研究旨在评估 OSA 患者的血浆 Aβ 1-40 和 Aβ 1-42 浓度。
怀疑患有 OSA 的患者（n = 112）接受了多导睡眠图检查。确诊为 OSA 的患者（n = 81）的呼吸暂停/低通气指数大于或等于 5。当 AHI 为 5-30 时，将疾病的轻度和中度形式定义为（n = 38，OSA+），当 AHI 大于 30 时，定义为重度（n = 43，OSA++）。AHI<5 的个体（n = 31）作为对照组（OSA-）。
OSA++组（191.1 pg/ml）的 Aβ 1-40 浓度明显高于 OSA-组（76.9 pg/ml）和 OSA+组（159.4 pg/ml）（p<0.05），且与低氧血症严重程度的某些参数相关。各组间 Aβ 1-42 浓度无差异。
在重度 OSA 患者中，与 OSA-和 OSA+相比，血浆 Aβ 1-40 浓度明显升高，且似乎与缺氧严重程度有关，这可能表明该组患者 AD 发病风险增加。
