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头颈部鳞状细胞癌中 CTTN/皮质肌动蛋白改变的预后和临床病理意义：系统评价和荟萃分析。

Prognostic and clinicopathological significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta-analysis.

机构信息

School of Dentistry, University of Granada, Granada, Spain.

Instituto de Investigación Biosanitaria, Granada, Spain.

出版信息

Head Neck. 2019 Jun;41(6):1963-1978. doi: 10.1002/hed.25632. Epub 2018 Dec 30.

DOI:10.1002/hed.25632
PMID:30597652
Abstract

BACKGROUND

To evaluate the prognostic significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma (HNSCC).

MATERIAL AND METHODS

We searched PubMed, Embase, Web of Science, and Scopus for studies published before May 2018. We conducted a meta-analysis to quantify the impact of CTTN/cortactin alterations on clinicopathological and survival variables.

RESULTS

Eighteen studies (1633 patients) met inclusion criteria. Quantitative evaluation revealed a strong association of CTTN/cortactin alterations with N+ status (P < .001), higher T status (P < .001), advanced clinical stage (P < .001), high histological grade (P = .001), and lower overall survival (OS) (P < .001). We found heterogeneity in T status, histological grade, and OS and observed small-study effects on N status and OS. In subgroup analyses, a significant association of CTTN amplification and cortactin overexpression with the above variables was preserved. The strongest association between CTTN/cortactin alterations and a worse outcome was observed in the subgroups of Asian patients and pharyngolaryngeal squamous cell carcinomas.

CONCLUSIONS

CTTN/cortactin alterations should be evaluated to predict the HNSCC prognosis.

摘要

背景

评估 CTTN/桩蛋白改变对头颈鳞状细胞癌（HNSCC）的预后意义。

材料与方法

我们在 PubMed、Embase、Web of Science 和 Scopus 上搜索了截至 2018 年 5 月发表的研究。我们进行了荟萃分析，以量化 CTTN/桩蛋白改变对临床病理和生存变量的影响。

结果

18 项研究（1633 名患者）符合纳入标准。定量评估显示 CTTN/桩蛋白改变与 N+状态（P<0.001）、更高的 T 分期（P<0.001）、晚期临床分期（P<0.001）、高组织学分级（P=0.001）和较低的总生存期（OS）（P<0.001）密切相关。我们发现 T 分期、组织学分级和 OS 存在异质性，并且 N 分期和 OS 存在小样本效应。在亚组分析中，CTTN 扩增和桩蛋白过表达与上述变量的显著相关性得以保留。在亚洲患者和咽扁桃体鳞状细胞癌亚组中，CTTN/桩蛋白改变与预后较差的相关性最强。

结论

应该评估 CTTN/桩蛋白改变以预测 HNSCC 的预后。

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