Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Department of Pathology & Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Head Neck. 2021 Sep;43(9):2688-2697. doi: 10.1002/hed.26746. Epub 2021 May 19.
In this feasibility study we aimed to evaluate the value of previously reported molecular tumor biomarkers associated with lymph node metastasis in oral squamous cell carcinoma (OSCC) to optimize neck strategy selection criteria.
The association between expression of cortactin, cyclin D1, FADD, RAB25, and S100A9 and sentinel lymph node status was evaluated in a series of 87 (cT1-2N0) patients with OSCC treated with primary resection and SLNB procedure.
Tumor infiltration depth and tumor pattern of invasion were independent prognostic markers for SLN status, while none of the tumor makers showed a better prognostic value to replace SLNB as neck staging technique in the total cohort. However, in the subgroup of patients with pT1N0 OSCC, cortactin expression (OR 16.0, 95%CI 2.0-127.9) was associated with SLN classification.
Expression of cortactin is a promising immunohistochemical tumor marker to identify patients at low risk that may not benefit from SLNB or END.
在这项可行性研究中，我们旨在评估与淋巴结转移相关的先前报道的分子肿瘤标志物在口腔鳞状细胞癌（OSCC）中的价值，以优化颈部策略选择标准。
在一系列接受原发切除术和 SLNB 手术治疗的 87 例（cT1-2N0）OSCC 患者中，评估了桩蛋白、细胞周期蛋白 D1、FADD、RAB25 和 S100A9 的表达与前哨淋巴结状态之间的关系。
肿瘤浸润深度和肿瘤侵袭模式是 SLN 状态的独立预后标志物，而没有任何肿瘤标志物显示出比 SLNB 更好的预后价值，可以替代 SLNB 作为颈部分期技术在总队列中使用。然而，在 pT1N0 OSCC 患者亚组中，桩蛋白表达（OR 16.0，95%CI 2.0-127.9）与 SLN 分类相关。
桩蛋白的表达是一种很有前途的免疫组织化学肿瘤标志物，可以识别出低风险的患者，这些患者可能不需要 SLNB 或 END。
