Department of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Mar;127(3):231-236. doi: 10.1016/j.oooo.2018.11.004. Epub 2018 Nov 16.
Odontogenic tumors bear some histopathologic and molecular resemblance to craniopharyngiomas. Specifically, adamantinomatous craniopharyngioma shares morphologic features and CTNNB1 (the gene encoding β-catenin) mutations with calcifying odontogenic cyst, whereas papillary craniopharyngioma and ameloblastoma are driven by BRAF mutations. Recently, important similarities between adamantinomatous craniopharyngioma and the cell signaling pathways involved in tooth formation have been described. Here, we expand the interpretation of these data in the context of odontogenic tumors. We discuss some morphologic and molecular features that are shared by tumors from these 2 distinct sites (i.e., craniopharyngiomas and odontogenic tumors). Current conservative surgical treatment is effective in most cases of benign odontogenic tumors, but in the future, the understanding of the molecular pathogenesis could impact the treatment of aggressive and/or malignant cases.
牙源性肿瘤在组织病理学和分子水平上与颅咽管瘤有一定的相似性。具体来说，造釉细胞瘤具有与牙源性钙化囊肿相似的形态特征和 CTNNB1（编码β-连环蛋白的基因）突变，而乳头状颅咽管瘤和造釉细胞瘤则受 BRAF 突变驱动。最近，牙源性肿瘤形成的细胞信号通路与造釉细胞瘤之间的重要相似性已经被描述。在这里，我们在牙源性肿瘤的背景下扩展了对这些数据的解释。我们讨论了这两个不同部位（即颅咽管瘤和牙源性肿瘤）的肿瘤所共有的一些形态学和分子特征。目前，对于大多数良性牙源性肿瘤，保守的手术治疗是有效的，但在未来，对分子发病机制的理解可能会影响侵袭性和/或恶性病例的治疗。
