Paulus W, Stöckel C, Krauss J, Sörensen N, Roggendorf W
Division of Neuropathology, University of Erlangen, Germany.
Histopathology. 1997 Feb;30(2):172-6. doi: 10.1046/j.1365-2559.1997.d01-584.x.
Based on the striking histological similarity of craniopharyngiomas and some odontogenic tumours, we reclassified a series of 54 craniopharyngiomas (52 adamantinomatous and two papillary variants) according to the WHO classification of odontogenic tumours. Twenty-seven tumours (50%) corresponded histologically to calcifying odontogenic cyst. 13 tumours (24%) to ameloblastoma, and eight (15%) tumours showed features of both calcifying odontogenic cyst and ameloblastoma either within the same specimen or in specimens derived from different resections. Rare tumours included three cases resembling calcifying epithelial odontogenic tumour and one case resembling adenomatoid odontogenic tumour. No odontogenic counterpart could be established for papillary craniopharyngiomas. The two major subtypes, i.e. craniopharyngioma corresponding to calcifying odontogenic cyst and craniopharyngioma corresponding to ameloblastoma, did not differ in their basic clinical features. Our data confirm and extend the close histological resemblance between adamantinomatous craniopharyngioma and odontogenic tumours and cysts. Furthermore, although calcifying odontogenic cyst and ameloblastoma arising in the jaw differ in clinical presentation and outcome, our study did not reveal clinical differences for the corresponding subtypes of craniopharyngioma.
基于颅咽管瘤与某些牙源性肿瘤显著的组织学相似性，我们根据世界卫生组织牙源性肿瘤分类法，对一系列54例颅咽管瘤（52例成釉细胞瘤型和2例乳头型）进行了重新分类。27例肿瘤（50%）在组织学上符合钙化牙源性囊肿。13例肿瘤（24%）符合成釉细胞瘤，8例（15%）肿瘤在同一标本或不同切除标本中表现出钙化牙源性囊肿和成釉细胞瘤的特征。罕见肿瘤包括3例类似钙化上皮性牙源性肿瘤的病例和1例类似腺样牙源性肿瘤的病例。乳头型颅咽管瘤无法确定其对应的牙源性肿瘤。两种主要亚型，即符合钙化牙源性囊肿的颅咽管瘤和符合成釉细胞瘤的颅咽管瘤，其基本临床特征并无差异。我们的数据证实并扩展了成釉细胞瘤型颅咽管瘤与牙源性肿瘤及囊肿之间紧密的组织学相似性。此外，尽管颌骨中发生的钙化牙源性囊肿和成釉细胞瘤在临床表现和预后方面存在差异，但我们的研究并未揭示相应亚型颅咽管瘤的临床差异。
