Malvindi Pietro Giorgio, Margari Vito, Mastro Florinda, Visicchio Giuseppe, Kounakis Georgios, Favale Antonella, Dambruoso Pierpaolo, Labriola Cataldo, Carbone Carmine, Paparella Domenico
Division of Cardiac Surgery, Santa Maria Hospital, GVM Care & Research, Bari, Italy.
Department of Emergency and Organ Transplant, University of Bari Aldo Moro, Bari, Italy.
Ann Cardiothorac Surg. 2018 Nov;7(6):748-754. doi: 10.21037/acs.2018.10.09.
Minimally invasive cardiac surgery has increasingly been used for patients with valvular pathology. Two techniques of aortic occlusion are utilized with this technique: transthoracic aortic clamp (TTC) and endoaortic balloon occlusion (EAO). Both possibilities present peculiar advantages and limitations whose current evidence is based on few observational studies. We performed an analysis with the primary objective to evaluate outcomes and the incidence of major complications of these two techniques.
The data of 258 patients who underwent minimally invasive mitral valve surgery through right mini-thoracotomy from January 2013 to July 2018 were reviewed. One hundred sixty-five patients were operated on with TTC and in 93 cases EAO was used. Univariate and multivariate analyses were performed to identify predictors of adverse outcome.
The mean age of the cohort was 60.4±13.9 years, patients with TTC were significantly older and had higher EuroSCORE II and reoperations were carried out mostly with EAO. Isolated mitral valve surgery was mostly performed (74%) and in 26% of the cases, other procedures were combined. No differences were detected in terms of types of operation, cardiopulmonary bypass (CPB) and cross-clamp times between the two techniques. Similar postoperative troponin I and CK-Mb values were recorded. Twenty-four patients (11%) suffered at least one complication. Of note, a new neurologic deficit occurred in six patients; in four cases a cerebral stroke, with all patients in the EAO group (P=0.06). There was no case of aortic dissection, no patient suffered peripheral ischemia nor femoral vessels complications. Thirty-day mortality was 1.9% (TTC 1.2% EAO 3.2%; P=0.51), 30-day mortality excluding reoperations was 1.2% (TTC 1.2% EAO 1.1%; P=0.61).
Both techniques proved to be safe. Although non-statistically significant, there was a higher rate of cerebral stroke in the EAO group. However, EAO system shows technical advantages in avoiding tissue dissection and remains our choice in redo operations.
微创心脏手术越来越多地应用于患有瓣膜病变的患者。该技术采用两种主动脉阻断技术:经胸主动脉钳夹(TTC)和主动脉内球囊阻断(EAO)。这两种方法都有其独特的优点和局限性,目前的证据基于少数观察性研究。我们进行了一项分析,主要目的是评估这两种技术的结果和主要并发症的发生率。
回顾了2013年1月至2018年7月期间258例通过右胸小切口接受微创二尖瓣手术患者的数据。165例患者采用TTC手术,93例采用EAO手术。进行单因素和多因素分析以确定不良结局的预测因素。
队列的平均年龄为60.4±13.9岁,TTC组患者年龄显著更大,欧洲心脏手术风险评估系统(EuroSCORE)II评分更高,再次手术大多采用EAO。大多数患者(74%)接受单纯二尖瓣手术,26%的病例合并其他手术。两种技术在手术类型、体外循环(CPB)和阻断时间方面未发现差异。术后肌钙蛋白I和肌酸激酶同工酶(CK-Mb)值相似。24例患者(11%)至少发生一种并发症。值得注意的是,6例患者出现新的神经功能缺损;4例发生脑卒,均在EAO组(P=0.06)。无主动脉夹层病例,无患者发生外周缺血或股血管并发症。30天死亡率为1.9%(TTC组1.2%,EAO组3.2%;P=0.51),排除再次手术的30天死亡率为1.2%(TTC组1.2%,EAO组1.1%;P=0.61)。
两种技术均被证明是安全的。虽然无统计学意义,但EAO组的脑卒中发生率较高。然而,EAO系统在避免组织解剖方面显示出技术优势,仍然是我们再次手术的选择。