Matsuzaki Junko, Ku Matthew, Berman Jeffrey I, Blaskey Lisa, Bloy Luke, Chen Yu-Han, Dell John, Edgar J Christopher, Kuschner Emily S, Liu Song, Saby Joni, Brodkin Edward S, Roberts Timothy P L
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Neurosci Lett. 2019 Apr 17;698:140-145. doi: 10.1016/j.neulet.2018.12.043. Epub 2018 Dec 29.
The auditory mismatch field (MMF) is a pre-attentive processing component, reflecting neural discrimination and inhibitory processing. Abnormal MMFs have been reported in children with autism spectrum disorder (ASD) along with an association with abnormal language comprehension; however, relatively little is known about MMF abnormalities to contrasting vowel stimuli in adults with ASD. To better understand the neurophysiological mechanisms underlying auditory language discrimination of vowel stimuli in individuals with ASD, magnetoencephalography was used to measure MMFs during an auditory oddball paradigm with vowel stimuli (/a/ and /u/) in adults with ASD. MMFs arising from left and right superior temporal gyrus are reported from nine high-functioning right handed males with ASD (22.22 ± 5.74yrs) and sixteen typically developing (TD) right handed males (27.25 ± 6.63yrs). The MMF was delayed in adults with ASD (188.90 ± 5.8 ms) as compared to the TD participants (173.08 ± 4.31 ms, p < 0.05). Replicating previous findings in children, the earlier M100 component to single stimulus tokens was also delayed in adults with ASD (108.59 ± 4.1 ms) compared to the TD participants (94.60 ± 3.0 ms, p < 0.05). However, there was no correlation between delayed M100 latency and MMF latency. Furthermore, whereas TD participants showed a leftward lateralization of MMF amplitude, participants with ASD showed an opposite (rightward) lateralization. Findings suggest that adults with ASD have hemispherically- and temporally- abnormal auditory discrimination processing in addition to and distinct from abnormal neurophysiological mechanisms in earlier cortical responses.
听觉失匹配负波（MMF）是一种前注意加工成分，反映神经辨别和抑制加工。已有报道称，自闭症谱系障碍（ASD）儿童存在MMF异常，且与语言理解异常有关；然而，对于ASD成人对比元音刺激时的MMF异常情况，人们了解相对较少。为了更好地理解ASD个体对元音刺激进行听觉语言辨别的神经生理机制，研究人员利用脑磁图在听觉oddball范式中测量了ASD成人对元音刺激（/a/和/u/）的MMF。报告了9名高功能右利手ASD男性（22.22±5.74岁）和16名典型发育（TD）右利手男性（27.25±6.63岁）左右颞上回产生的MMF。与TD参与者（173.08±4.31毫秒，p<0.05）相比，ASD成人的MMF延迟（188.90±5.8毫秒）。与之前在儿童中的研究结果一致，ASD成人对单个刺激标记的早期M100成分也比TD参与者延迟（108.59±4.1毫秒）（94.60±3.0毫秒，p<0.05）。然而，M100潜伏期延迟与MMF潜伏期之间没有相关性。此外，TD参与者的MMF振幅表现为左侧化，而ASD参与者则表现为相反的（右侧化）。研究结果表明，ASD成人除了早期皮层反应中的异常神经生理机制外，还存在半球和时间上异常的听觉辨别加工，且与后者不同。
