a School of Life Science and Biotechnology , Yangtze Normal University , Chongqing , China.
b School of Clinical Medicine , Jining Medical University , Jining , China.
Int J Food Sci Nutr. 2019 May;70(3):311-322. doi: 10.1080/09637486.2018.1511688. Epub 2019 Jan 2.
The ingestion of tea flavonoids (TF) and fructooligosaccharide (FOS) contributes to anti-hyperlipidaemia. In the current study, TF or FOS or TF together with FOS were orally administrated to mice fed a high sucrose (HS) diet. UPLC-MS analyses showed that FOS significantly increased the concentrations of urine catechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate and gallocatechin gallate. The mice fed with HS for continuous 8 weeks exhibited severe dyslipidemia and abnormal liver fat accumulation. However, oral administration of FOS or TF or in combination significantly decreased the effects of HS on the serum total cholesterol, total triglycerides, low-density lipoprotein and high-density lipoprotein. Co-treatment of FOS and TF more effectively regulated lipid metabolism by inhibiting lipogenesis. Intake of TF together with FOS reduced the level of dyslipidemia marker (elaidic acid) by increasing anti-oxidative activity than treatments of FOS or TP alone in HS-fed mice. Histological observations of liver confirmed these health benefits.
摄入茶类黄酮（TF）和低聚果糖（FOS）有助于抗高血脂。在本研究中，向喂食高蔗糖（HS）饮食的小鼠口服 TF 或 FOS 或 TF 与 FOS 的混合物。UPLC-MS 分析表明，FOS 显著增加了尿儿茶素、表没食子儿茶素、表儿茶素没食子酸酯、表没食子儿茶素没食子酸酯和没食子儿茶素没食子酸酯的浓度。连续 8 周喂食 HS 的小鼠表现出严重的血脂异常和异常的肝脂肪堆积。然而，FOS 或 TF 或联合口服给药显著降低了 HS 对血清总胆固醇、总甘油三酯、低密度脂蛋白和高密度脂蛋白的影响。FOS 和 TF 的共同处理通过抑制脂肪生成更有效地调节脂质代谢。与 FOS 或 TP 单独处理相比，TF 与 FOS 一起摄入可通过增加抗氧化活性来降低 HS 喂养小鼠的血脂异常标志物（反油酸）的水平。肝组织学观察证实了这些健康益处。
