Li Wenfeng, Zhang Wanjie, Fan Xin, Xu Hai, Yuan Hong, Wang Yimeng, Yang Rui, Tian Hua, Wu Yinmei, Yang Hongyan
School of Life Science and Biotechnology, Yangtze Normal University, Chongqing 408100, China.
Faculty of Science, The University of Hong Kong, Hong Kong 999077, China.
Food Chem X. 2023 Jul 3;19:100765. doi: 10.1016/j.fochx.2023.100765. eCollection 2023 Oct 30.
The anthocyanins from red radish (ARR) rich in polyglycosylated pelargonidin glucosides were used as pigment. However, bioavailability of anthocyanins was considered at low level. This work examined the intensive effects of fructo-oligosaccharide (FOS) on ARR bioavailability. Pelargonidin, cyanidin and pelargonidin-3-glucoside showed higher level in serum of mice fed with FOS together with ARR for 8 weeks than that fed with only ARR. Co-ingestion of FOS and ARR more effectively elevated the hepatic antioxidant activity by increase in total antioxidant capacity and activities of superoxide dismutase and glutathione peroxidase when compared with intake of ARR. FOS also markedly increased pelargonidin level in cecum of mice. 16S RNA sequencing found that genus play an important role in FOS elevating bioavailability of ARR. Fecal bacteria transplantation verified the positive effects of FOS on ARR bioavailability. These results suggested that combined ingestion of FOS and ARR is effective strategy for bioactivity of ARR.
富含多聚糖化天竺葵素糖苷的红萝卜花青素（ARR）被用作色素。然而，花青素的生物利用度被认为处于较低水平。这项工作研究了低聚果糖（FOS）对ARR生物利用度的强化作用。与仅喂食ARR的小鼠相比，同时喂食FOS和ARR 8周的小鼠血清中天竺葵素、矢车菊素和天竺葵素-3-葡萄糖苷的水平更高。与摄入ARR相比，同时摄入FOS和ARR通过提高总抗氧化能力以及超氧化物歧化酶和谷胱甘肽过氧化物酶的活性，更有效地提高了肝脏抗氧化活性。FOS还显著提高了小鼠盲肠中天竺葵素的水平。16S RNA测序发现，某属在FOS提高ARR生物利用度方面发挥着重要作用。粪便细菌移植证实了FOS对ARR生物利用度的积极影响。这些结果表明，同时摄入FOS和ARR是提高ARR生物活性的有效策略。
