Conte-Delvox B, Olivier C, Codaccioni J L
Endocrinologie et maladies métaboliques, Hôpital de la Conception, Marseille.
Ann Endocrinol (Paris). 1988;49(4-5):408-11.
Experimental diabetes in animals induces marked alterations of gonadal androgenic functions: reduction in testis weight, morphological alterations of Leydig cells, decrease of plasma testosterone levels and reduction of the ability of the Leydig cells to secrete testosterone in vitro. hCG treatment restores the testicular endocrine function; in addition several morphological and functional changes are observed in the hypothalamic-hypophyseal-gonadal axis which are probably responsible for the testicular lesions found in untreated experimental diabetes mellitus. In diabetic men, the hypothalamic-hypophyseal-gonadal axis seems to be normal (with exception of individual cases); Mean plasma levels of testosterone, LH, FSH and the responses of the gonadal axis to hCG and LHRH are normal.
睾丸重量减轻、莱迪希细胞形态改变、血浆睾酮水平降低以及莱迪希细胞体外分泌睾酮能力下降。人绒毛膜促性腺激素（hCG）治疗可恢复睾丸内分泌功能；此外，下丘脑-垂体-性腺轴会出现一些形态和功能变化，这些变化可能是未经治疗的实验性糖尿病中发现的睾丸病变的原因。在糖尿病男性中，下丘脑-垂体-性腺轴似乎是正常的（个别病例除外）；睾酮、促黄体生成素（LH）、促卵泡生成素（FSH）的平均血浆水平以及性腺轴对hCG和促性腺激素释放激素（LHRH）的反应均正常。
