肾移植后的生长与内分泌功能
Growth and endocrine function after renal transplantation.
作者信息
Rees L, Greene S A, Adlard P, Jones J, Haycock G B, Rigden S P, Preece M, Chantler C
机构信息
Evelina Children's Hospital, United Medical School, London.
出版信息
Arch Dis Child. 1988 Nov;63(11):1326-32. doi: 10.1136/adc.63.11.1326.
Abstract
Longitudinal height data and physical development were assessed in 45 boys and 34 girls after renal transplantation. All children received alternate day steroids and either azathioprine or cyclosporin A for immunosuppression. There was a significant increase in growth velocity after transplantation in prepubertal children. Growth velocity declined at the expected age of the normal pubertal growth spurt, however, with delay in the appearance of secondary sexual characteristics. Overnight hormone profiles in 17 adolescent subjects with short stature or maturational delay, or both, showed blunting of growth hormone and gonadotrophin pulsatility. It is likely that long term steroid treatment after renal transplantation induces the clinical and endocrine picture of delayed puberty. Failure of growth to accelerate at this time is a cause of short stature, which may have an effect on adult height.
摘要
对45名接受肾移植的男孩和34名接受肾移植的女孩进行了纵向身高数据和身体发育评估。所有儿童均隔天接受类固醇治疗，并使用硫唑嘌呤或环孢素A进行免疫抑制。青春期前儿童移植后的生长速度显著增加。然而，在正常青春期生长突增的预期年龄，生长速度下降，同时第二性征出现延迟。对17名身材矮小或发育延迟或两者兼有的青少年受试者进行的夜间激素谱分析显示，生长激素和促性腺激素的脉冲性减弱。肾移植后长期使用类固醇治疗可能会导致青春期延迟的临床和内分泌表现。此时生长未能加速是身材矮小的一个原因，这可能会影响成人身高。
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