Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, No. 106 Zhong Shan Er Road, Guangzhou, 510080, Guangdong, China.
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N University Blvd, Indianapolis, IN, 46202, USA.
Abdom Radiol (NY). 2019 Mar;44(3):967-975. doi: 10.1007/s00261-018-1879-3.
To use MRCP to investigate age-related changes and gender differences of the pancreas and to correlate pancreatic gland size and duct diameter.
In this institutional review, board-approved, HIPAA-compliant study, 280 patients (age 20-88 years) without a history of pancreatic or liver disease who had undergone MRI/MRCP from 2004 to 2015 were identified. The anteroposterior size and main duct diameter of the pancreatic head, body, and tail were measured. The pancreatic gland and duct sizes were compared between genders, and among seven age subgroups (20-29, 30-39, 40-49, 50-59, 60-69, 70-79, 80-89).
The pancreatic head and body were significantly larger in males than females (head, p < 0.01; body, p = 0.03), while the tail and the duct diameters of the pancreatic head, body, and tail showed no gender difference. As the age of male participants increased, there was an associated increase in size of the pancreatic gland initially (largest at age 50-59 (body) and 60-69 (head)), followed by subsequent decline in size thereafter. Additionally, the pancreatic duct diameter was found to increase gradually. In females, the size of the pancreatic gland decreased, while the diameter of the pancreatic duct increased with age. Moderate positive correlation for gland size and strong positive correlation for duct diameter among different pancreatic regions were found. Weak negative correlation was found between gland size and duct diameter.
There are gender differences in the gland size of the pancreatic head and body. The pancreatic gland size increases until the sixth decade in males, with a more continuous decrease in gland size with age in females. Both males and females demonstrate a marked decrease in gland size after the eighth decade. The duct diameter increases with age in both males and females.
使用磁共振胰胆管成像（MRCP）研究胰腺的年龄相关性变化和性别差异，并对胰腺腺体量和胰管直径进行相关性分析。
在这项机构审查、委员会批准、符合 HIPAA 标准的研究中，我们确定了 280 名（年龄 20-88 岁）无胰腺或肝脏疾病病史、2004 年至 2015 年间接受 MRI/MRCP 的患者。测量胰头部、体部和尾部的前后径大小和主胰管直径。比较了不同性别和 7 个年龄亚组（20-29 岁、30-39 岁、40-49 岁、50-59 岁、60-69 岁、70-79 岁、80-89 岁）之间的胰腺腺体量和胰管大小。
男性胰头部和体部明显大于女性（头部，p<0.01；体部，p=0.03），而胰尾部和胰头部、体部和尾部的胰管直径无性别差异。随着男性参与者年龄的增加，胰腺腺体量最初呈递增趋势（50-59 岁（体部）和 60-69 岁（头部）最大），随后逐渐减小。此外，胰管直径逐渐增大。女性的胰腺腺体量减小，而胰管直径随年龄增长而增大。不同胰腺区域的腺体量呈中度正相关，胰管直径呈强正相关。腺体量和胰管直径之间存在弱负相关。
胰头部和体部的胰腺腺体量存在性别差异。男性的胰腺腺体量在 60 岁之前增加，女性的胰腺腺体量则持续减少。男女均在 80 岁以后胰腺腺体量明显减小。男女的胰管直径均随年龄增长而增大。
