一维 Fe P 可响应近红外二区光和超声作为 Fenton 试剂用于深部肿瘤协同治疗。
One-Dimensional Fe P Acts as a Fenton Agent in Response to NIR II Light and Ultrasound for Deep Tumor Synergetic Theranostics.
机构信息
State Key Laboratory of Rare Earth Resource Utilization, Changchun, Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, China.
University of Science and Technology of China, Hefei, 230026, Anhui, China.
出版信息
Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2407-2412. doi: 10.1002/anie.201813702. Epub 2019 Jan 21.
The stringent reaction conditions for an effective Fenton reaction (pH range of 3-4) hinders its application in cancer therapy. Therefore, how to improve the efficiency of the Fenton reaction in a tumor site has been the main obstacle in chemodynamic therapy (CDT). Herein, we report biocompatible one-dimensional (1D) ferrous phosphide nanorods (FP NRs) with ultrasound (US)- and photothermal (PT)-enhanced Fenton properties and excellent photothermal conversion efficiency (56.6 %) in the NIR II window, showing synergistic therapeutic properties. Additionally, the high photothermal conversion efficiency and excellent traverse relaxivity (277.79 mm s ) of the FP NRs means they are excellent photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) agents. This is the first report on exploiting the response of metallic phosphides to NIR II laser (1064 nm) and ultrasound to improve the CDT effect with a high therapeutic effect and PA/MR imaging.
在有效的芬顿反应（pH 值范围为 3-4）条件下，反应条件非常苛刻，这阻碍了其在癌症治疗中的应用。因此，如何提高肿瘤部位芬顿反应的效率一直是化学动力学治疗（CDT）的主要障碍。在此，我们报道了生物相容性的一维（1D）二价磷化亚铁纳米棒（FP NRs），它具有超声（US）和光热（PT）增强的芬顿性质和优异的光热转换效率（56.6%）在近红外二区（NIR Ⅱ）窗口，表现出协同治疗特性。此外，FP NRs 的高光热转换效率和出色的横向弛豫率（277.79 mm s ）意味着它们是优秀的光声成像（PAI）和磁共振成像（MRI）造影剂。这是首次利用金属磷化物对近红外二区激光（1064 nm）和超声的响应来提高 CDT 效应的报告，具有高治疗效果和 PA/MR 成像。
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