蛋白酶抑制剂Ras蛋白可能参与恶性转化。
Possible involvement of protease inhibitor ras proteins in malignant transformation.
作者信息
Hiwasa T
机构信息
Division of Biochemistry, Chiba Cancer Center Research Institute, Japan.
出版信息
Biol Chem Hoppe Seyler. 1988 May;369 Suppl:239-41.
PMID:3060139
Abstract
Based on our recent finding that human c-Ha-ras gene products (p21s) inhibit the activities of thiol proteinases, a possible new model for malignant transformation is proposed. The model involves a new concept that p21s can cause effects on the protein kinase activities of growth factor receptors by affecting down regulation of the receptors.
摘要
基于我们最近的发现，即人类c-Ha-ras基因产物（p21s）可抑制巯基蛋白酶的活性，我们提出了一种可能的恶性转化新模型。该模型涉及一个新概念，即p21s可通过影响生长因子受体的下调来对其蛋白激酶活性产生影响。
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