组织蛋白酶L样蛋白酶对表皮生长因子受体的降解作用：c-Ha-ras基因产物对该降解作用的抑制
Degradation of epidermal growth factor receptors by cathepsin L-like protease: inhibition of the degradation by c-Ha-ras gene products.
作者信息
Hiwasa T, Sakiyama S, Yokoyama S, Ha J M, Noguchi S, Bando Y, Kominami E, Katunuma N
机构信息
Division of Biochemistry, Chiba Cancer Center Research Institute, Japan.
出版信息
FEBS Lett. 1988 Jun 20;233(2):367-70. doi: 10.1016/0014-5793(88)80462-9.
PMID:3289971
Abstract
Extract of NIH3T3 mouse fibroblasts contains a protease which can cleave epidermal growth factor receptor (EGF receptor). This protease was tentatively named cathepsin X and purified to near homogeneity. The characteristics of cathepsin X were similar to those of cathepsin L and the proteolytic activity of cathepsin X was inhibited by c-Ha-ras gene products.
摘要
NIH3T3小鼠成纤维细胞提取物中含有一种能切割表皮生长因子受体（EGF受体）的蛋白酶。这种蛋白酶被暂命名为组织蛋白酶X，并被纯化至接近均一。组织蛋白酶X的特性与组织蛋白酶L相似，且其蛋白水解活性受到c-Ha-ras基因产物的抑制。
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