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用于测量可变形颗粒弹性模量的微流控装置的设计。

Design of a microfluidic device for the measurement of the elastic modulus of deformable particles.

机构信息

Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università di Napoli Federico II, P. le Tecchio 80, 80125 Napoli, Italy.

出版信息

Soft Matter. 2019 Jan 30;15(5):880-889. doi: 10.1039/c8sm02272k.

DOI:10.1039/c8sm02272k
PMID:30601566
Abstract

A microfluidic technique recently proposed in the literature to measure the interfacial tension between a liquid droplet and an immiscible suspending liquid [Hudson et al., Appl. Phys. Lett., 2005, 87, 081905], [Cabral and Hudson, Lab Chip, 2006, 6, 427] is suitably adapted to the characterization of the elastic modulus of soft particles in a continuous-flow process. A microfluidic device consisting of a cylindrical pipe with a reduction in cross-section is designed, and the deformation and velocity of incompressible elastic particles suspended in a Newtonian liquid are tracked as they move along the centerline through the constriction. Kinematic and shape information is exploited to calculate the particle's elastic modulus by means of the theory of elastic particle deformation in extensional flow. The approach is validated for different orders of magnitude of the elastic capillary number through experiments and numerical simulations.

摘要

一种微流控技术最近在文献中被提出,用于测量液滴和不混溶悬浮液之间的界面张力[Hudson 等人,应用物理快报,2005 年,87,081905],[Cabral 和 Hudson,芯片实验室,2006 年,6,427],适用于在连续流过程中表征软颗粒的弹性模量。设计了一种由带有截面减小的圆柱管组成的微流控装置,并跟踪不可压缩弹性颗粒在牛顿液体中沿中心线通过收缩段的变形和速度。通过实验和数值模拟,利用运动学和形状信息,根据拉伸流中弹性颗粒变形的理论,计算颗粒的弹性模量。该方法通过实验和数值模拟验证了不同数量级的弹性毛细数的有效性。

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