Cao Gao-Juan, Chen Yingmei, Chen Xiaohe, Weng Peilin, Lin Rong-Guang
a Department of Applied Chemistry, College of Life Sciences , Fujian Agriculture and Forestry University , Fuzhou , Fujian , China.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2019;37(1):14-25. doi: 10.1080/10590501.2019.1555319. Epub 2019 Jan 2.
Noble metal nanoparticles (NPs) and their hybrids have demonstrated a strong potential to mimic the catalytic activity of natural enzymes and diminish oxidative stress. There is a large space to explore the intrinsic catalytic activity of Rh NPs with respect to reactive oxygen species (ROS) scavenging. We found that Rh NPs can quench HO, OH, O, O and inhibit lipid peroxidation under physiological conditions. In vitro cell experiments proved that Rh NPs have great biocompatibility and protect cells from oxidative damage caused by HO. This study can provide important insights that could inform future biological applications.
贵金属纳米颗粒（NPs）及其杂化物已显示出模拟天然酶催化活性并减轻氧化应激的强大潜力。在活性氧（ROS）清除方面，探索铑纳米颗粒的内在催化活性还有很大空间。我们发现铑纳米颗粒在生理条件下可以淬灭羟基自由基（HO·）、超氧阴离子自由基（O₂·⁻）、单线态氧（¹O₂），并抑制脂质过氧化。体外细胞实验证明铑纳米颗粒具有良好的生物相容性，可保护细胞免受羟基自由基（HO·）引起的氧化损伤。本研究可为未来的生物学应用提供重要见解。
