Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Medical Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, Berlin, Germany.
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Nat Cell Biol. 2019 Jan;21(1):94-101. doi: 10.1038/s41556-018-0249-2. Epub 2019 Jan 2.
Cellular senescence is implicated in physiological and pathological processes spanning development, wound healing, age-related decline in organ functions and cancer. Here, we discuss cell-autonomous and non-cell-autonomous properties of senescence in the context of tumour formation and anticancer therapy, and characterize these properties, such as reprogramming into stemness, tissue remodelling and immune crosstalk, as far more dynamic than suggested by the common view of senescence as an irreversible, static condition.
细胞衰老与贯穿发育、伤口愈合、与年龄相关的器官功能下降和癌症等生理和病理过程有关。在这里，我们讨论了衰老在肿瘤形成和抗癌治疗背景下的自主和非自主特性，并将这些特性（如重新编程为干性、组织重塑和免疫串扰）描述为比衰老作为一种不可逆的、静态状态的常见观点所暗示的更为动态。
