去衰老化：揭开肿瘤抑制？

UnSASPing Senescence: Unmasking Tumor Suppression?

机构信息

Charité Universitätsmedizin Berlin, Department of Hematology, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum (MKFZ), Augustenburger Platz 1, 13353 Berlin, Germany; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Robert-Rössle Straße, 1013125 Berlin, Germany; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Berlin, Germany.

出版信息

Cancer Cell. 2018 Jul 9;34(1):6-8. doi: 10.1016/j.ccell.2018.06.009.

DOI:10.1016/j.ccell.2018.06.009

PMID:29990502

Abstract

Cellular senescence serves as a barrier to tumor development and a principle effector of anti-cancer therapy, but the largely pro-inflammatory senescence-associated secretory phenotype (SASP) may drive tumor promotion and contribute to age-related pathologies. In this issue of Cancer Cell, Georgilis et al. present SASP-deprived senescence as a potential therapeutic perspective.

摘要

细胞衰老作为肿瘤发展的障碍和抗癌治疗的主要效应器，但主要的炎症性衰老相关分泌表型 (SASP) 可能会促进肿瘤生长，并导致与年龄相关的病理。在本期《癌细胞》中，Georgilis 等人提出了剥夺 SASP 的衰老作为一种潜在的治疗观点。