地中海贫血患者血清不对称二甲基精氨酸与肌钙蛋白I水平与心肌梗死风险的关联

Association of serum asymmetric dimethyl-arginine and troponin I levels as a risk of myocardial infarction in thalassemia.

作者信息

Helmi Nawal, Choudhry Hani, Qari M, Kumosani Taha A, Al-Malki Abdulrahman L, Moselhy Said Salama, Kumosani Afnan T

机构信息

Biochemistry Department, Faculty of science, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi Arabia.

Cancer Metabolism and Epigenetic Unit, Faculty of Science (KAU) ; Cancer and Mutagenesis Unit, King Fahd Medical Research Center (KAU).

出版信息

Afr Health Sci. 2018 Sep;18(3):720-726. doi: 10.4314/ahs.v18i3.30.

DOI:10.4314/ahs.v18i3.30

PMID:30603005

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6307029/

Abstract

BACKGROUND

The current study evaluated level of serum asymmetric dimethylarginine (ADMA) and its association to cardiac biomarkers in thalassemia patients for early diagnosis of abnormality in myocardial infarction.

SUBJECTS AND METHODS

This study was conducted on 80 subjects divided into four groups each with 20 subjects. Group I: Control: healthy subjects. Group II: Myocardial infarction: Patients with elevated serum troponin T. Group III: thalassemia patients. Group IV: thalassemia with myocardial infarction patients: Included 20 thalassemia patients with Myocardial infarction. Serum samples were subjected for assay of creatine kinase (CK:MB), Lactate dehydrogenase, troponin I, ADMA, Serum MDA level was determined.

RESULTS

Data obtained showed that serum CKMB, LDH1, AST, Troponin T and ADMA levels were significant elevated in MI with or without Thalassemia compared with control groups. Serum MDA was statistically significantly elevated in MI with or without Thalassemia compared with control groups. The serum level of troponin T showed an area under curve (AUC) of 0.92, (sensitivity 91.0 % and specificity, 88%). Also, the ADMA supported the diagnostic profile, showing an AUC of 0.85 with (sensitivity, 92.0%; specificity, 91,9%).

CONCLUSION

Serum ADMA is sensitive marker for incidence of MI in thalassemia patients.

摘要

背景

本研究评估了地中海贫血患者血清不对称二甲基精氨酸（ADMA）水平及其与心脏生物标志物的关联，以早期诊断心肌梗死异常情况。

对象与方法

本研究对80名受试者进行，分为四组，每组20名。第一组：对照组：健康受试者。第二组：心肌梗死组：血清肌钙蛋白T升高的患者。第三组：地中海贫血患者组。第四组：地中海贫血合并心肌梗死患者组：包括20名合并心肌梗死的地中海贫血患者。采集血清样本检测肌酸激酶（CK:MB）、乳酸脱氢酶、肌钙蛋白I、ADMA，测定血清丙二醛水平。

结果

获得的数据显示，与对照组相比，无论有无地中海贫血的心肌梗死患者血清CKMB、LDH1、AST、肌钙蛋白T和ADMA水平均显著升高。无论有无地中海贫血的心肌梗死患者血清丙二醛与对照组相比均有统计学显著升高。肌钙蛋白T血清水平曲线下面积（AUC）为0.92，（敏感性91.0%，特异性88%）。此外，ADMA支持诊断特征，AUC为0.85，（敏感性92.0%；特异性91.9%）。