Huang Lei, Teng Tianming, Zhao Jinyan, Bian Bo, Yao Wei, Yu Xuefang, Wang Zhuoqun, Xu Zhelong, Sun Yuemin
Department of Cardiology, Tianjin Medical University General Hospital, China.
Department of Physiology & Pathophysiology, Tianjin Medical University, Tianjin, China.
Heart Lung Circ. 2018 Jan;27(1):66-72. doi: 10.1016/j.hlc.2017.01.022. Epub 2017 Mar 12.
Zinc is one of the most important microelements in the body and zinc homeostasis plays a critical role in maintaining cellular structure and function. Zinc dyshomeostasis can lead to many diseases, such as cardiovascular disease. Our aim was to investigate whether there is a relationship between zinc and cardiac markers, and the risk of acute myocardial infarction (AMI) by zinc quartiles.
We enrolled a total of 529 patients and measured their serum zinc levels and cardiac markers. We performed further studies after dividing subjects into four groups according to their concentrations of zinc by quartile to clarify the relationship between zinc levels and risk of increased acute myocardial infarction prevalence rate.
We observed that there was a significant inverse linear relationship between zinc and Lg(creatine kinase) (p=0.011), Lg(creatine kinase-MB) (p=0.002) and Lg(cardiac troponin T) (p=0.045). In addition, the acute myocardial infarction prevalence rates were 28.8%, 24.8%, 20.5%, and 18.2% by patients with zinc quartiles, respectively. Multivariate logistic regression analysis showed that the odds ratio between the lowest and highest zinc quartile groups was 1.92 (1.019-3.604) (p<0.05).
The present study revealed a relationship between serum zinc levels in that zinc levels were significantly inversely correlated with serum creatine kinase (CK), creatine kinase-MB (CKMB) and cardiac troponin T (cTnT) levels. Furthermore, we found that the prevalence rate of acute myocardial infarction decreased with increasing zinc quartiles.
锌是人体最重要的微量元素之一，锌稳态在维持细胞结构和功能方面起着关键作用。锌稳态失衡会导致许多疾病，如心血管疾病。我们的目的是研究锌与心脏标志物之间是否存在关系，以及按锌四分位数分组时急性心肌梗死（AMI）的风险。
我们共纳入529例患者，测量他们的血清锌水平和心脏标志物。根据锌浓度将受试者按四分位数分为四组后进行进一步研究，以阐明锌水平与急性心肌梗死患病率增加风险之间的关系。
我们观察到锌与Lg（肌酸激酶）（p = 0.011）、Lg（肌酸激酶同工酶MB）（p = 0.002）和Lg（心肌肌钙蛋白T）（p = 0.045）之间存在显著的负线性关系。此外，按锌四分位数分组的患者急性心肌梗死患病率分别为28.8%、24.8%、20.5%和18.2%。多因素逻辑回归分析显示，最低和最高锌四分位数组之间的比值比为1.92（1.019 - 3.604）（p < 0.05）。
本研究揭示了血清锌水平之间的关系，即锌水平与血清肌酸激酶（CK）、肌酸激酶同工酶MB（CKMB）和心肌肌钙蛋白T（cTnT）水平显著负相关。此外，我们发现急性心肌梗死的患病率随着锌四分位数的增加而降低。
