Nishikawa Tomofumi, Okamura T, Shima A, Kawatsu Y, Sugiyama D, Kadota A, Morimoto A, Tatsumi Y, Godai K, Miyamatsu N
1Department of Health and Nutrition, Kyoto Koka Women's University, 38 Kadonocho, Nishikyogoku, Ukyo-Ku, Kyoto, 615-0822 Japan.
4Department of Clinical Nursing, Shiga University of Medical Science, Otsu, Japan.
Diabetol Int. 2015 Nov 18;7(3):252-258. doi: 10.1007/s13340-015-0241-z. eCollection 2016 Sep.
The utility of casual serum triglyceride (TG) as a predictor of type 2 diabetes mellitus (DM) is unclear, especially during the most productive years.
Participants were 3271 workers (913 men and 2358 women, age 20-57) without DM at baseline. They underwent consecutive annual medical check-ups for 8 years. The association between newly diagnosed DM and casual serum TG level was determined by classifying the participants into 4 groups according to casual serum TG level at baseline: below 50 mg/dL (group A), 50-100 mg/dL (group B), 100-150 mg/dL (group C), and ≥150 mg/dL (group D). The effects of casual serum TG level in combination with sex, obesity, or serum glucose level on newly diagnosed DM were also evaluated.
A total of 222 newly diagnosed type 2 DM cases with a mean age of 50 years old were observed during the follow-up period, i.e., 10/406 in group A, 66/1534 in group B, 58/712 in group C, and 88/619 in group D. Compared with group A, the odds ratio (ORs) for newly diagnosed DM (after adjusting for DM-associated factors) was found to increase with casual serum TG level: 1.38 (group B), 1.79 (group C), and 2.36 (group D). Moreover, the OR for newly diagnosed DM was higher in participants with high casual serum TG levels who were also male (OR 2.46), obese (OR 4.18), or had a high serum glucose level (OR 6.96) than in the reference group.
Serum TG level ≥150 mg/dL when fasting or nonfasting is a significant predictor of type 2 diabetes in middle-aged Japanese workers.
随机血清甘油三酯（TG）作为2型糖尿病（DM）预测指标的效用尚不清楚，尤其是在工作效率最高的年龄段。
研究对象为3271名基线时无DM的工作人员（913名男性和2358名女性，年龄20 - 57岁）。他们连续接受了8年的年度体检。根据基线时的随机血清TG水平将参与者分为4组：低于50mg/dL（A组）、50 - 100mg/dL（B组）、100 - 150mg/dL（C组）和≥150mg/dL（D组），以确定新诊断的DM与随机血清TG水平之间的关联。还评估了随机血清TG水平与性别、肥胖或血糖水平相结合对新诊断DM的影响。
随访期间共观察到222例新诊断的2型DM病例，平均年龄50岁，即A组406例中有10例，B组1534例中有66例，C组712例中有58例，D组619例中有88例。与A组相比，发现新诊断DM的比值比（OR）随随机血清TG水平升高而增加（调整DM相关因素后）：B组为1.38，C组为1.79，D组为2.36。此外，随机血清TG水平高且为男性（OR 2.46）、肥胖（OR 4.18）或血糖水平高（OR 6.96）的参与者中新诊断DM的OR高于参照组。
空腹或非空腹时血清TG水平≥150mg/dL是日本中年工作人员2型糖尿病的重要预测指标。
