注射锝标记的完整单克隆抗体及其片段后人体暴露情况的评估。
Assessment of exposure after injection of Tc-labeled intact monoclonal antibodies and their fragments into humans.
作者信息
Mostafa Mostafa Y A, Zakaly Hesham M H, Zhukovsky Michael
机构信息
Department of Experimental Physics, Institute of Physics and Technology, Ural Federal University, Yekaterinburg, 620002, Russia.
Department of Physics, Faculty of Science, Minia University, El-Minia, Egypt.
出版信息
Radiol Phys Technol. 2019 Mar;12(1):96-104. doi: 10.1007/s12194-018-00496-1. Epub 2019 Jan 2.
Human pharmacokinetics and internal radiation dosimetry of normal organs after injection with the Tc-labeled monoclonal antibody (intact and fragments) are simulated by the WinAct program and IDAC (Internal Dose Assessment by Computer) software. The WinAct program is used to calculate the cumulative activity in organs and tissues. The calculated cumulative activity is inputted to the IDAC software, an internal dosimetry program for nuclear medicine based on the International Commission on Radiological Protection (ICRP) adult reference voxel phantom, and the absorbed doses by the organs and tissues are estimated. The obtained absorbed doses for the Tc-labeled monoclonal antibody (intact and fragments) are compared with the published figures by ICRP-128. The WinAct program method to calculate the cumulative activity is more accurate, as the fraction distribution, F, is described and calculated for organs, not only for intake, as in the ICRP model, but also for elimination.
通过WinAct程序和IDAC（计算机内部剂量评估）软件模拟注射Tc标记的单克隆抗体（完整抗体和片段）后正常器官的人体药代动力学和体内辐射剂量学。WinAct程序用于计算器官和组织中的累积活度。将计算得到的累积活度输入到IDAC软件中，该软件是基于国际放射防护委员会（ICRP）成人参考体素模型的核医学内部剂量学程序，用于估算器官和组织的吸收剂量。将获得的Tc标记单克隆抗体（完整抗体和片段）的吸收剂量与ICRP - 128公布的数据进行比较。WinAct程序计算累积活度的方法更准确，因为它不仅像ICRP模型那样描述和计算了器官的摄入分数分布F，还计算了消除分数分布F。
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