Lescroart Fabienne, Zaffran Stephane
Aix Marseille Univ, INSERM, MMG U1251, Marseille, France.
Int J Dev Biol. 2018;62(11-12):837-846. doi: 10.1387/ijdb.180192sz.
Hox genes are highly conserved transcription factors with critical functions during development, in particular for patterning the antero-posterior axis of the embryo. Their action is very often associated with cofactors including the TALE family transcription factors. From Drosophila to vertebrates, Hox genes have been shown to have a major role in heart development. In this review, we focus on the increasing evidence implicating the anterior Hox genes and the Tale family members during heart development both in the cardiac mesoderm and in neural crest cells. Congenital heart defects are the leading cause of death in the first year of life and a better understanding of the role of Hox and Tale factors is highly relevant to human pathologies and will provide novel mechanistic insights into the underlying defects.
Hox基因是高度保守的转录因子，在发育过程中具有关键功能，尤其是在胚胎前后轴的模式形成中。它们的作用常常与包括TALE家族转录因子在内的辅因子相关。从果蝇到脊椎动物，Hox基因已被证明在心脏发育中起主要作用。在本综述中，我们重点关注越来越多的证据，这些证据表明心脏中胚层和神经嵴细胞在心脏发育过程中涉及前Hox基因和Tale家族成员。先天性心脏缺陷是一岁以内婴儿死亡的主要原因，更好地理解Hox和Tale因子的作用与人类病理学高度相关，并将为潜在缺陷提供新的机制见解。
