Lehmann H G, Kuwert E K, Hennessen W, Widmark R
MMW Munch Med Wochenschr. 1978 Mar 3;120(9):289-92.
A rabies HDC vaccine purified by density gradient centrifugation was used before and after exposure and the antigenic activity and tolerance investigated. Three injections on days 0, 7 and 21 induced neutralizing antibodies between 1:100 and 1: less than 1000 with 100% conversion rate, while one injection is sufficient for a booster. Vaccination after exposure is described; simultaneous passive immunization does not imply inhibition of the active immune response. Quantifiable local and general reactions seldom occur and serious neurological complications are not to be expected.
一种通过密度梯度离心法纯化的狂犬病HDC疫苗在暴露前后使用，并对其抗原活性和耐受性进行了研究。在第0、7和21天进行三次注射可诱导出1:100至1:小于1000的中和抗体，转化率为100%，而一次注射就足以进行加强免疫。文中描述了暴露后的疫苗接种情况；同时进行被动免疫并不意味着会抑制主动免疫反应。很少发生可量化的局部和全身反应，也预计不会出现严重的神经并发症。
