Pharmerit International, Rotterdam, the Netherlands.
Guy's and St Thomas' NHS Foundation Trust, London, UK.
Qual Life Res. 2019 May;28(5):1155-1177. doi: 10.1007/s11136-018-2081-3. Epub 2019 Jan 3.
There is a lack of performance comparisons of the generic quality of life tool EQ-5D-5L against disease- and treatment-specific measures in venous thromboembolism (VTE). The aim of this study was to compare EQ-5D-5L against the pulmonary embolism (PE)-specific PEmb-QoL and the deep vein thrombosis (DVT)-specific VEINES-QOL/Sym, and PACT-Q2 (treatment-specific) questionnaires in five language settings.
PREFER in VTE was a non-interventional disease registry conducted between 2013 and 2014 in primary and secondary care across seven European countries with five languages, including English, French, German, Italian and Spanish. Consecutive patients with acute PE/DVT were enrolled and followed over 12 months. Only patients who completed all three questionnaires at baseline were included in the study sample. The psychometric properties examined included acceptability (missing, ceiling and floor effects), validity (convergent and known-groups validity), and responsiveness. Known groups validity and responsiveness were assessed using both effect size (Cohen's d) and relative efficiency (F-statistic). All analyses were conducted in each language version and the total sample across all languages.
A total of 1054 PE and 1537 DVT patients were included. 14% of PE and 10% of DVT patients had the maximum EQ-5D-5L index score. EQ-5D-5L was low to moderately correlated with other measures (r < 0.5). EQ-5D-5L was associated with larger effect size/relative efficiency in most of known group comparisons in both VTE groups. Similar results were observed for responsiveness. EQ-5D-5L performed relatively better in French, Italian and Spanish language versions.
Overall EQ-5D-5L is comparable to PEmb-QoL, VEINES-QOL/Sym and PACT-Q2 in terms of acceptability, validity and responsiveness in both PE and DVT populations in English, French, German, Italian and Spanish language version. Nevertheless, it should be noted that each measure is designed to capture different aspects of health-related quality of life.
在静脉血栓栓塞症（VTE）中，缺乏通用生活质量工具 EQ-5D-5L 与疾病和治疗特异性措施的性能比较。本研究的目的是在五种语言环境下，比较 EQ-5D-5L 与肺栓塞（PE）特异性 PEmb-QoL 和深静脉血栓形成（DVT）特异性 VEINES-QOL/Sym 以及 PACT-Q2（治疗特异性）问卷。
VTE 中的 PREFER 是一项于 2013 年至 2014 年在七个欧洲国家的初级和二级保健机构进行的非干预性疾病登记研究，涵盖英语、法语、德语、意大利语和西班牙语五种语言。纳入了急性 PE/DVT 患者，并在 12 个月内进行随访。仅在基线时完成了所有三个问卷的患者被纳入研究样本。检查的心理测量学特性包括可接受性（缺失、上限和下限效应）、有效性（收敛性和已知群体有效性）和反应性。使用效应量（Cohen's d）和相对效率（F 统计量）评估了已知群体有效性和反应性。所有分析均在每种语言版本和所有语言的总样本中进行。
共纳入 1054 例 PE 和 1537 例 DVT 患者。14%的 PE 和 10%的 DVT 患者的 EQ-5D-5L 指数得分达到最高。EQ-5D-5L 与其他措施的相关性较低至中度（r < 0.5）。在两个 VTE 组的大多数已知组比较中，EQ-5D-5L 与更大的效应量/相对效率相关。在反应性方面也观察到了类似的结果。在法语、意大利语和西班牙语版本中，EQ-5D-5L 的表现相对较好。
总体而言，EQ-5D-5L 在英语、法语、德语、意大利语和西班牙语版本中，在可接受性、有效性和反应性方面，与 PE 和 DVT 人群中的 PEmb-QoL、VEINES-QOL/Sym 和 PACT-Q2 相当。然而，需要注意的是，每种措施都是为了捕捉健康相关生活质量的不同方面。
