Wang Shu-Yun, Li Guo-Yu, Zhang Ke, Wang Hang-Yu, Liang Hong-Gang, Huang Chao, Huang Jian, Wang Jin-Hui, Yang Bao-Feng
School of Pharmacy, Henan University , Kaifeng 475004 , China.
Department of Medicinal Chemistry and Natural Medicine Chemistry (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University , Harbin 832001 , China.
J Asian Nat Prod Res. 2019 Nov;21(11):1075-1082. doi: 10.1080/10286020.2018.1498084. Epub 2019 Jan 4.
Two new ingol-type diterpenes, euphoresins A-B (-), have been isolated from the methanol extract of , the latex of Berg. Their structures were established on the basis of extensive analyses of their HR-ESI-MS, IR, UV, 1D, and 2D NMR spectra. The absolute configurations were confirmed by Mosher's method and circular dichroism (CD) analyses. The two compounds were tested for their cytotoxic activities against MCF-7, U937, and C6 cancer cell lines, but they both exhibited little cytotoxic effect.
从大戟科大戟属植物Berg的乳汁甲醇提取物中分离出两种新的英戈尔型二萜类化合物，大戟树脂A - B（-）。通过对其高分辨电喷雾电离质谱（HR - ESI - MS）、红外光谱（IR）、紫外光谱（UV）、一维和二维核磁共振谱（1D和2D NMR）进行广泛分析确定了它们的结构。通过莫舍尔法和圆二色性（CD）分析确定了绝对构型。测试了这两种化合物对MCF - 7、U937和C6癌细胞系的细胞毒性活性，但它们均表现出微弱的细胞毒性作用。
